SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood an...

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Autores principales: Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O’Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0b3b94e948d5442aa6b0f00f729b8c20
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spelling oai:doaj.org-article:0b3b94e948d5442aa6b0f00f729b8c202021-12-02T14:08:59ZSARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques10.1038/s41467-020-20642-x2041-1723https://doaj.org/article/0b3b94e948d5442aa6b0f00f729b8c202021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20642-xhttps://doaj.org/toc/2041-1723Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.Yashavanth Shaan LakshmanappaSonny R. ElizaldiJamin W. RohBrian A. SchmidtTimothy D. CarrollKourtney D. WeaverJustin C. SmithAnil VermaJesse D. DeereJoseph DutraMars StoneSergej FranzRebecca Lee SammakKatherine J. OlstadJ. Rachel ReaderZhong-Min MaNancy K. NguyenJennifer WatanabeJodie UsachenkoRamya ImmareddyJoAnn L. YeeDaniela WeiskopfAlessandro SetteDennis Hartigan-O’ConnorStephen J. McSorleyJohn H. MorrisonNam K. TranGraham SimmonsMichael P. BuschPamela A. KozlowskiKoen K. A. Van RompayChristopher J. MillerSmita S. IyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yashavanth Shaan Lakshmanappa
Sonny R. Elizaldi
Jamin W. Roh
Brian A. Schmidt
Timothy D. Carroll
Kourtney D. Weaver
Justin C. Smith
Anil Verma
Jesse D. Deere
Joseph Dutra
Mars Stone
Sergej Franz
Rebecca Lee Sammak
Katherine J. Olstad
J. Rachel Reader
Zhong-Min Ma
Nancy K. Nguyen
Jennifer Watanabe
Jodie Usachenko
Ramya Immareddy
JoAnn L. Yee
Daniela Weiskopf
Alessandro Sette
Dennis Hartigan-O’Connor
Stephen J. McSorley
John H. Morrison
Nam K. Tran
Graham Simmons
Michael P. Busch
Pamela A. Kozlowski
Koen K. A. Van Rompay
Christopher J. Miller
Smita S. Iyer
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
description Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.
format article
author Yashavanth Shaan Lakshmanappa
Sonny R. Elizaldi
Jamin W. Roh
Brian A. Schmidt
Timothy D. Carroll
Kourtney D. Weaver
Justin C. Smith
Anil Verma
Jesse D. Deere
Joseph Dutra
Mars Stone
Sergej Franz
Rebecca Lee Sammak
Katherine J. Olstad
J. Rachel Reader
Zhong-Min Ma
Nancy K. Nguyen
Jennifer Watanabe
Jodie Usachenko
Ramya Immareddy
JoAnn L. Yee
Daniela Weiskopf
Alessandro Sette
Dennis Hartigan-O’Connor
Stephen J. McSorley
John H. Morrison
Nam K. Tran
Graham Simmons
Michael P. Busch
Pamela A. Kozlowski
Koen K. A. Van Rompay
Christopher J. Miller
Smita S. Iyer
author_facet Yashavanth Shaan Lakshmanappa
Sonny R. Elizaldi
Jamin W. Roh
Brian A. Schmidt
Timothy D. Carroll
Kourtney D. Weaver
Justin C. Smith
Anil Verma
Jesse D. Deere
Joseph Dutra
Mars Stone
Sergej Franz
Rebecca Lee Sammak
Katherine J. Olstad
J. Rachel Reader
Zhong-Min Ma
Nancy K. Nguyen
Jennifer Watanabe
Jodie Usachenko
Ramya Immareddy
JoAnn L. Yee
Daniela Weiskopf
Alessandro Sette
Dennis Hartigan-O’Connor
Stephen J. McSorley
John H. Morrison
Nam K. Tran
Graham Simmons
Michael P. Busch
Pamela A. Kozlowski
Koen K. A. Van Rompay
Christopher J. Miller
Smita S. Iyer
author_sort Yashavanth Shaan Lakshmanappa
title SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
title_short SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
title_full SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
title_fullStr SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
title_full_unstemmed SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
title_sort sars-cov-2 induces robust germinal center cd4 t follicular helper cell responses in rhesus macaques
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0b3b94e948d5442aa6b0f00f729b8c20
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