Recent Advances in Neonatal Diabetes

Amanda Dahl, Seema Kumar Division of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USACorrespondence: Seema KumarDivision of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 20...

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Autores principales:	Dahl A, Kumar S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neonatal diabetes kcnj11 sulfonylurea abcc8 Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0b3c84cbc9d14acda99b18608e9d81bf
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spelling	oai:doaj.org-article:0b3c84cbc9d14acda99b18608e9d81bf2021-12-02T05:31:25ZRecent Advances in Neonatal Diabetes1178-7007https://doaj.org/article/0b3c84cbc9d14acda99b18608e9d81bf2020-02-01T00:00:00Zhttps://www.dovepress.com/recent-advances-in-neonatal-diabetes-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Amanda Dahl, Seema Kumar Division of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USACorrespondence: Seema KumarDivision of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55590, USA Tel +1 507-284-3300Fax +1 507-284-0727Email kumar.seema@mayo.eduAbstract: Neonatal diabetes mellitus (DM) is defined by the onset of persistent hyperglycemia within the first six months of life but may present up to 12 months of life. A gene mutation affecting pancreatic beta cells or synthesis/secretion of insulin is present in more than 80% of the children with neonatal diabetes. Neonatal DM can be transient, permanent, or be a component of a syndrome. Genetic testing is important as a specific genetic mutation can significantly alter the treatment and outcome. Patients with mutations of either KCNJ11 or ABCC8 that encode subunits of the KATP channel gene mutation can be managed with sulfonylurea oral therapy while patients with other genetic mutations require insulin treatment.Keywords: neonatal diabetes, KCNJ11, sulfonylurea, ABCC8Dahl AKumar SDove Medical Pressarticleneonatal diabeteskcnj11sulfonylureaabcc8Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 355-364 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neonatal diabetes kcnj11 sulfonylurea abcc8 Specialties of internal medicine RC581-951
spellingShingle	neonatal diabetes kcnj11 sulfonylurea abcc8 Specialties of internal medicine RC581-951 Dahl A Kumar S Recent Advances in Neonatal Diabetes
description	Amanda Dahl, Seema Kumar Division of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USACorrespondence: Seema KumarDivision of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55590, USA Tel +1 507-284-3300Fax +1 507-284-0727Email kumar.seema@mayo.eduAbstract: Neonatal diabetes mellitus (DM) is defined by the onset of persistent hyperglycemia within the first six months of life but may present up to 12 months of life. A gene mutation affecting pancreatic beta cells or synthesis/secretion of insulin is present in more than 80% of the children with neonatal diabetes. Neonatal DM can be transient, permanent, or be a component of a syndrome. Genetic testing is important as a specific genetic mutation can significantly alter the treatment and outcome. Patients with mutations of either KCNJ11 or ABCC8 that encode subunits of the KATP channel gene mutation can be managed with sulfonylurea oral therapy while patients with other genetic mutations require insulin treatment.Keywords: neonatal diabetes, KCNJ11, sulfonylurea, ABCC8
format	article
author	Dahl A Kumar S
author_facet	Dahl A Kumar S
author_sort	Dahl A
title	Recent Advances in Neonatal Diabetes
title_short	Recent Advances in Neonatal Diabetes
title_full	Recent Advances in Neonatal Diabetes
title_fullStr	Recent Advances in Neonatal Diabetes
title_full_unstemmed	Recent Advances in Neonatal Diabetes
title_sort	recent advances in neonatal diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0b3c84cbc9d14acda99b18608e9d81bf
work_keys_str_mv	AT dahla recentadvancesinneonataldiabetes AT kumars recentadvancesinneonataldiabetes
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Recent Advances in Neonatal Diabetes

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