Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas

Aberrant reprogramming of metabolism has been considered a hallmark in various malignant tumors. The metabolic changes of amino acid not only have dramatic effects in cancer cells but also influence their immune-microenvironment in gliomas. However, the features of the amino acid metabolism-related...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang Xu, Liguo Ye, Rongxin Geng, Ping Hu, Qian Sun, Shiao Tong, Fanen Yuan, Qianxue Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gliomas gene signature amino acid metabolism prognosis microenvironment immune Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0b4507cfb0c647729e19fa18367bfb7a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0b4507cfb0c647729e19fa18367bfb7a
record_format	dspace
spelling	oai:doaj.org-article:0b4507cfb0c647729e19fa18367bfb7a2021-11-05T07:17:13ZDevelopment and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas2234-943X10.3389/fonc.2021.774332https://doaj.org/article/0b4507cfb0c647729e19fa18367bfb7a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.774332/fullhttps://doaj.org/toc/2234-943XAberrant reprogramming of metabolism has been considered a hallmark in various malignant tumors. The metabolic changes of amino acid not only have dramatic effects in cancer cells but also influence their immune-microenvironment in gliomas. However, the features of the amino acid metabolism-related and immune-associated gene set have not been systematically described. The expression level of mRNA was obtained from The Cancer Genome Atlas database and the Chinese Glioma Genome Atlas database, which were used as training set and validation set, respectively. Different bioinformatics and statistical methods were combined to construct a robust amino metabolism-related and immune-associated risk signature for distinguishing prognosis and clinical pathology features. Constructing the nomogram enhanced risk stratification and quantified risk assessment based on our gene model. Besides this, the biological mechanism related to the risk score was investigated by gene set enrichment analysis. Hub genes of risk signature were identified by the protein–protein interaction network. The amino acid metabolism-related and immune-associated gene signature recognized high-risk patients, defined as an independent risk factor for overall survival. The nomogram exhibited a high accuracy in predicting the overall survival rate for glioma patients. Furthermore, the high risk score hinted an immunosuppressive microenvironment and a lower sensitivity of immune checkpoint blockade therapy and also identified PSMC5 and PSMD3 as novel biomarkers in glioma. In conclusion, a novel amino acid metabolism-related and immune-associated risk signature for predicting prognosis in glioma has been constructed and identified as two potential novel biomarkers.Yang XuLiguo YeRongxin GengPing HuQian SunShiao TongFanen YuanQianxue ChenFrontiers Media S.A.articlegliomasgene signatureamino acid metabolismprognosismicroenvironmentimmuneNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gliomas gene signature amino acid metabolism prognosis microenvironment immune Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	gliomas gene signature amino acid metabolism prognosis microenvironment immune Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang Xu Liguo Ye Rongxin Geng Ping Hu Qian Sun Shiao Tong Fanen Yuan Qianxue Chen Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
description	Aberrant reprogramming of metabolism has been considered a hallmark in various malignant tumors. The metabolic changes of amino acid not only have dramatic effects in cancer cells but also influence their immune-microenvironment in gliomas. However, the features of the amino acid metabolism-related and immune-associated gene set have not been systematically described. The expression level of mRNA was obtained from The Cancer Genome Atlas database and the Chinese Glioma Genome Atlas database, which were used as training set and validation set, respectively. Different bioinformatics and statistical methods were combined to construct a robust amino metabolism-related and immune-associated risk signature for distinguishing prognosis and clinical pathology features. Constructing the nomogram enhanced risk stratification and quantified risk assessment based on our gene model. Besides this, the biological mechanism related to the risk score was investigated by gene set enrichment analysis. Hub genes of risk signature were identified by the protein–protein interaction network. The amino acid metabolism-related and immune-associated gene signature recognized high-risk patients, defined as an independent risk factor for overall survival. The nomogram exhibited a high accuracy in predicting the overall survival rate for glioma patients. Furthermore, the high risk score hinted an immunosuppressive microenvironment and a lower sensitivity of immune checkpoint blockade therapy and also identified PSMC5 and PSMD3 as novel biomarkers in glioma. In conclusion, a novel amino acid metabolism-related and immune-associated risk signature for predicting prognosis in glioma has been constructed and identified as two potential novel biomarkers.
format	article
author	Yang Xu Liguo Ye Rongxin Geng Ping Hu Qian Sun Shiao Tong Fanen Yuan Qianxue Chen
author_facet	Yang Xu Liguo Ye Rongxin Geng Ping Hu Qian Sun Shiao Tong Fanen Yuan Qianxue Chen
author_sort	Yang Xu
title	Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
title_short	Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
title_full	Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
title_fullStr	Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
title_full_unstemmed	Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas
title_sort	development and verification of the amino metabolism-related and immune-associated prognosis signature in gliomas
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0b4507cfb0c647729e19fa18367bfb7a
work_keys_str_mv	AT yangxu developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT liguoye developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT rongxingeng developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT pinghu developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT qiansun developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT shiaotong developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT fanenyuan developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas AT qianxuechen developmentandverificationoftheaminometabolismrelatedandimmuneassociatedprognosissignatureingliomas
_version_	1718444451674718208

Development and Verification of the Amino Metabolism-Related and Immune-Associated Prognosis Signature in Gliomas

Ejemplares similares