Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation to a challenging metastatic microenvironment, whic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Erin N. Howe, Miranda D. Burnette, Melanie E. Justice, Patricia M. Schnepp, Victoria Hedrick, James W. Clancy, Ian H. Guldner, Alicia T. Lamere, Jun Li, Uma K. Aryal, Crislyn D’Souza-Schorey, Jeremiah J. Zartman, Siyuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b460feafbd444f4b8cc9b1a57749999
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0b460feafbd444f4b8cc9b1a57749999
record_format	dspace
spelling	oai:doaj.org-article:0b460feafbd444f4b8cc9b1a577499992021-12-02T16:04:12ZRab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth10.1038/s41467-020-16832-22041-1723https://doaj.org/article/0b460feafbd444f4b8cc9b1a577499992020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16832-2https://doaj.org/toc/2041-1723Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation to a challenging metastatic microenvironment, which can be exploited by repurposing statins.Erin N. HoweMiranda D. BurnetteMelanie E. JusticePatricia M. SchneppVictoria HedrickJames W. ClancyIan H. GuldnerAlicia T. LamereJun LiUma K. AryalCrislyn D’Souza-SchoreyJeremiah J. ZartmanSiyuan ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erin N. Howe Miranda D. Burnette Melanie E. Justice Patricia M. Schnepp Victoria Hedrick James W. Clancy Ian H. Guldner Alicia T. Lamere Jun Li Uma K. Aryal Crislyn D’Souza-Schorey Jeremiah J. Zartman Siyuan Zhang Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
description	Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation to a challenging metastatic microenvironment, which can be exploited by repurposing statins.
format	article
author	Erin N. Howe Miranda D. Burnette Melanie E. Justice Patricia M. Schnepp Victoria Hedrick James W. Clancy Ian H. Guldner Alicia T. Lamere Jun Li Uma K. Aryal Crislyn D’Souza-Schorey Jeremiah J. Zartman Siyuan Zhang
author_facet	Erin N. Howe Miranda D. Burnette Melanie E. Justice Patricia M. Schnepp Victoria Hedrick James W. Clancy Ian H. Guldner Alicia T. Lamere Jun Li Uma K. Aryal Crislyn D’Souza-Schorey Jeremiah J. Zartman Siyuan Zhang
author_sort	Erin N. Howe
title	Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
title_short	Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
title_full	Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
title_fullStr	Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
title_full_unstemmed	Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
title_sort	rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0b460feafbd444f4b8cc9b1a57749999
work_keys_str_mv	AT erinnhowe rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT mirandadburnette rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT melanieejustice rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT patriciamschnepp rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT victoriahedrick rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT jameswclancy rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT ianhguldner rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT aliciatlamere rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT junli rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT umakaryal rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT crislyndsouzaschorey rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT jeremiahjzartman rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth AT siyuanzhang rab11bmediatedintegrinrecyclingpromotesbrainmetastaticadaptationandoutgrowth
_version_	1718385252460658688

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Ejemplares similares