Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives

Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives

Widespread resistance of <i>Plasmodium falciparum</i> to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug–drug adverse interactions. In this...

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Bibliographic Details
Main Authors: Mohd Asyraf Shamsuddin, Amatul Hamizah Ali, Nur Hanis Zakaria, Mohd Fazli Mohammat, Ahmad Sazali Hamzah, Zurina Shaameri, Kok Wai Lam, Wun Fui Mark-Lee, Hani Kartini Agustar, Mohd Ridzuan Mohd Abd Razak, Jalifah Latip, Nurul Izzaty Hassan
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
4-aminoquinoline
antimalarial
docking
hybrid
pyrano[2,3-c]pyrazole
Medicine
R
Pharmacy and materia medica
RS1-441
Online Access:https://doaj.org/article/0b483ea7a6f6448e8959878be1c00bb5
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