Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease
Young Min Choe,1,2 Min Soo Byun,3 Jun Ho Lee,4 Bo Kyung Sohn,5 Dong Young Lee,3,4 Jee Wook Kim1,2 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Ko...
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Dove Medical Press
2018
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oai:doaj.org-article:0b49a75defa546ce94269362e6e41c312021-12-02T08:08:16ZSubjective memory complaint as a useful tool for the early detection of Alzheimer’s disease1178-2021https://doaj.org/article/0b49a75defa546ce94269362e6e41c312018-09-01T00:00:00Zhttps://www.dovepress.com/subjective-memory-complaint-as-a-useful-tool-for-the-early-detection-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Young Min Choe,1,2 Min Soo Byun,3 Jun Ho Lee,4 Bo Kyung Sohn,5 Dong Young Lee,3,4 Jee Wook Kim1,2 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea; 4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; 5Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea Purpose: Despite their high prevalence in Alzheimer’s disease (AD), and the increasing level of concern they have generated, subjective memory complaints (SMCs) are poorly understood. This study investigated the accuracy with which SMC can separate mild cognitive impairment (MCI) and early AD from cognitive normal (CN), and explored whether the discrimination ability is similar to or better than that of the Mini-Mental State Exam (MMSE).Patients and methods: This study recruited 175 CN subjects, 52 with MCI, and 66 with probable AD aged 60 years or older. To test the independent contributions of SMC and MMSE scores to the classification of cognitive status (CN vs MCI or early AD), logistic regression analyses were performed, adjusting for the following potential confounding variables: age, gender, Frontal Assessment Battery score, modified Hachinski Ischemic Scale score, and apolipoprotein E e4 status. Receiver operating characteristic (ROC) curve analyses were used to determine the discrimination accuracy of SMC and MMSE scores, and area under the ROC curve (AUROC) was also calculated.Results: In the highly educated (≥7 years), nondepressed (Geriatric Depression Scale ≤15) subgroup, SMC showed good accuracy in discriminating cognitively impaired subjects from CN after adjusting for potential confounding variables (the AUROC of the adjusted SMC was 0.841 for MCI discrimination, and it was 0.858 for MCI plus early AD discrimination). Both SMC and MMSE scores significantly contributed to differentiating between CN and MCI (OR=2.372, 95% CI=1.086–5.177; OR=0.730, 95% CI=0.566–0.941, respectively) after adjusting for the same covariates. However, in the highly educated and nondepressed subgroups, SMC showed significant predictive power for MCI from CN (OR=3.119, 95% CI=1.190–8.176; OR=3.328, 95% CI=1.320–8.396, respectively), whereas MMSE scores did not.Conclusion: Our findings support the usefulness of SMC, which was comparable or even superior to MMSE scores, for detecting MCI or early AD. Keywords: subjective memory complaint (SMC), Alzheimer’s disease (AD), mild cognitive impairment (MCI), cognitively normal (CN), discrimination accuracyChoe YMByun MSLee JHSohn BKLee DYKim JWDove Medical PressarticleSubjective memory complaint (SMC)Alzheimer’s disease (AD)mild cognitive impairment (MCI)cognitively normal (CN)discrimination accuracyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2451-2460 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Subjective memory complaint (SMC) Alzheimer’s disease (AD) mild cognitive impairment (MCI) cognitively normal (CN) discrimination accuracy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Subjective memory complaint (SMC) Alzheimer’s disease (AD) mild cognitive impairment (MCI) cognitively normal (CN) discrimination accuracy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Choe YM Byun MS Lee JH Sohn BK Lee DY Kim JW Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| description |
Young Min Choe,1,2 Min Soo Byun,3 Jun Ho Lee,4 Bo Kyung Sohn,5 Dong Young Lee,3,4 Jee Wook Kim1,2 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Republic of Korea; 4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; 5Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea Purpose: Despite their high prevalence in Alzheimer’s disease (AD), and the increasing level of concern they have generated, subjective memory complaints (SMCs) are poorly understood. This study investigated the accuracy with which SMC can separate mild cognitive impairment (MCI) and early AD from cognitive normal (CN), and explored whether the discrimination ability is similar to or better than that of the Mini-Mental State Exam (MMSE).Patients and methods: This study recruited 175 CN subjects, 52 with MCI, and 66 with probable AD aged 60 years or older. To test the independent contributions of SMC and MMSE scores to the classification of cognitive status (CN vs MCI or early AD), logistic regression analyses were performed, adjusting for the following potential confounding variables: age, gender, Frontal Assessment Battery score, modified Hachinski Ischemic Scale score, and apolipoprotein E e4 status. Receiver operating characteristic (ROC) curve analyses were used to determine the discrimination accuracy of SMC and MMSE scores, and area under the ROC curve (AUROC) was also calculated.Results: In the highly educated (≥7 years), nondepressed (Geriatric Depression Scale ≤15) subgroup, SMC showed good accuracy in discriminating cognitively impaired subjects from CN after adjusting for potential confounding variables (the AUROC of the adjusted SMC was 0.841 for MCI discrimination, and it was 0.858 for MCI plus early AD discrimination). Both SMC and MMSE scores significantly contributed to differentiating between CN and MCI (OR=2.372, 95% CI=1.086–5.177; OR=0.730, 95% CI=0.566–0.941, respectively) after adjusting for the same covariates. However, in the highly educated and nondepressed subgroups, SMC showed significant predictive power for MCI from CN (OR=3.119, 95% CI=1.190–8.176; OR=3.328, 95% CI=1.320–8.396, respectively), whereas MMSE scores did not.Conclusion: Our findings support the usefulness of SMC, which was comparable or even superior to MMSE scores, for detecting MCI or early AD. Keywords: subjective memory complaint (SMC), Alzheimer’s disease (AD), mild cognitive impairment (MCI), cognitively normal (CN), discrimination accuracy |
| format |
article |
| author |
Choe YM Byun MS Lee JH Sohn BK Lee DY Kim JW |
| author_facet |
Choe YM Byun MS Lee JH Sohn BK Lee DY Kim JW |
| author_sort |
Choe YM |
| title |
Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| title_short |
Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| title_full |
Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| title_fullStr |
Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| title_full_unstemmed |
Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease |
| title_sort |
subjective memory complaint as a useful tool for the early detection of alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/0b49a75defa546ce94269362e6e41c31 |
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