Electroretinographic findings in transplant chorioretinopathy

Brian T Chan-Kai1, Steven Yeh2, Richard G Weleber2, Peter J Francis2, Grazyna Adamus2, S Robert Witherspoon3, Andreas K Lauer11Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; 2Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; 3Retina Institute of Texas, D...

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Autores principales:	Brian T Chan-Kai, Steven Yeh, Richard G Weleber, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0b4becdb0a90422c8a9d2bf8b493bc1a
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spelling	oai:doaj.org-article:0b4becdb0a90422c8a9d2bf8b493bc1a2021-12-02T00:56:00ZElectroretinographic findings in transplant chorioretinopathy1177-54671177-5483https://doaj.org/article/0b4becdb0a90422c8a9d2bf8b493bc1a2010-07-01T00:00:00Zhttp://www.dovepress.com/electroretinographic-findings-in-transplant-chorioretinopathy-a4828https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Brian T Chan-Kai1, Steven Yeh2, Richard G Weleber2, Peter J Francis2, Grazyna Adamus2, S Robert Witherspoon3, Andreas K Lauer11Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; 2Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; 3Retina Institute of Texas, Dallas, Texas, USAAim: Transplant chorioretinopathy is a rare complication following solid organ or bone &shy;marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition.Methods: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus &shy;photography, and fluorescein angiography (FA) were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG) was obtained in two patients.Results: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed &shy;progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy.Conclusion: Transplant chorioretinopathy patients undergoing ERG testing show cone &shy;dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease.Keywords: transplant, chorioretinopathy, electroretinogram, ERG, mfERG Brian T Chan-KaiSteven YehRichard G Weleberet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 777-783 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Brian T Chan-Kai Steven Yeh Richard G Weleber et al Electroretinographic findings in transplant chorioretinopathy
description	Brian T Chan-Kai1, Steven Yeh2, Richard G Weleber2, Peter J Francis2, Grazyna Adamus2, S Robert Witherspoon3, Andreas K Lauer11Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; 2Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; 3Retina Institute of Texas, Dallas, Texas, USAAim: Transplant chorioretinopathy is a rare complication following solid organ or bone &shy;marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition.Methods: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus &shy;photography, and fluorescein angiography (FA) were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG) was obtained in two patients.Results: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed &shy;progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy.Conclusion: Transplant chorioretinopathy patients undergoing ERG testing show cone &shy;dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease.Keywords: transplant, chorioretinopathy, electroretinogram, ERG, mfERG
format	article
author	Brian T Chan-Kai Steven Yeh Richard G Weleber et al
author_facet	Brian T Chan-Kai Steven Yeh Richard G Weleber et al
author_sort	Brian T Chan-Kai
title	Electroretinographic findings in transplant chorioretinopathy
title_short	Electroretinographic findings in transplant chorioretinopathy
title_full	Electroretinographic findings in transplant chorioretinopathy
title_fullStr	Electroretinographic findings in transplant chorioretinopathy
title_full_unstemmed	Electroretinographic findings in transplant chorioretinopathy
title_sort	electroretinographic findings in transplant chorioretinopathy
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0b4becdb0a90422c8a9d2bf8b493bc1a
work_keys_str_mv	AT briantchankai electroretinographicfindingsintransplantchorioretinopathy AT stevenyeh electroretinographicfindingsintransplantchorioretinopathy AT richardgweleber electroretinographicfindingsintransplantchorioretinopathy AT etal electroretinographicfindingsintransplantchorioretinopathy
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Electroretinographic findings in transplant chorioretinopathy

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