Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.

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Autores principales:	Florian A. Lempp, Franziska Schlund, Lisa Rieble, Lea Nussbaum, Corinna Link, Zhenfeng Zhang, Yi Ni, Stephan Urban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b4c7b835d4c4558b301caf070bd4e81
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spelling	oai:doaj.org-article:0b4c7b835d4c4558b301caf070bd4e812021-12-02T17:32:40ZRecapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation10.1038/s41467-019-10211-22041-1723https://doaj.org/article/0b4c7b835d4c4558b301caf070bd4e812019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10211-2https://doaj.org/toc/2041-1723Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.Florian A. LemppFranziska SchlundLisa RiebleLea NussbaumCorinna LinkZhenfeng ZhangYi NiStephan UrbanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
description	Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.
format	article
author	Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban
author_facet	Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban
author_sort	Florian A. Lempp
title	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_short	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_full	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_fullStr	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_full_unstemmed	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_sort	recapitulation of hdv infection in a fully permissive hepatoma cell line allows efficient drug evaluation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0b4c7b835d4c4558b301caf070bd4e81
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Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

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