Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting visi...

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Autores principales: Gregory Gauvain, Himanshu Akolkar, Antoine Chaffiol, Fabrice Arcizet, Mina A. Khoei, Mélissa Desrosiers, Céline Jaillard, Romain Caplette, Olivier Marre, Stéphane Bertin, Claire-Maelle Fovet, Joanna Demilly, Valérie Forster, Elena Brazhnikova, Philippe Hantraye, Pierre Pouget, Anne Douar, Didier Pruneau, Joël Chavas, José-Alain Sahel, Deniz Dalkara, Jens Duebel, Ryad Benosman, Serge Picaud
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/0b4ca90d06f64da69afaff7c49d68f90
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spelling oai:doaj.org-article:0b4ca90d06f64da69afaff7c49d68f902021-12-02T10:47:53ZOptogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates10.1038/s42003-020-01594-w2399-3642https://doaj.org/article/0b4ca90d06f64da69afaff7c49d68f902021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01594-whttps://doaj.org/toc/2399-3642Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting vision restoration in patients with retinitis pigmentosa.Gregory GauvainHimanshu AkolkarAntoine ChaffiolFabrice ArcizetMina A. KhoeiMélissa DesrosiersCéline JaillardRomain CapletteOlivier MarreStéphane BertinClaire-Maelle FovetJoanna DemillyValérie ForsterElena BrazhnikovaPhilippe HantrayePierre PougetAnne DouarDidier PruneauJoël ChavasJosé-Alain SahelDeniz DalkaraJens DuebelRyad BenosmanSerge PicaudNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Gregory Gauvain
Himanshu Akolkar
Antoine Chaffiol
Fabrice Arcizet
Mina A. Khoei
Mélissa Desrosiers
Céline Jaillard
Romain Caplette
Olivier Marre
Stéphane Bertin
Claire-Maelle Fovet
Joanna Demilly
Valérie Forster
Elena Brazhnikova
Philippe Hantraye
Pierre Pouget
Anne Douar
Didier Pruneau
Joël Chavas
José-Alain Sahel
Deniz Dalkara
Jens Duebel
Ryad Benosman
Serge Picaud
Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
description Gauvain et al demonstrate that optogenetic therapy using the AAV2.7m8- ChR-tdT construct can partially restore vision in non-human primates to levels above those considered legally-blind. This study enables the identification of the most suitable construct for ongoing clinical trials attempting vision restoration in patients with retinitis pigmentosa.
format article
author Gregory Gauvain
Himanshu Akolkar
Antoine Chaffiol
Fabrice Arcizet
Mina A. Khoei
Mélissa Desrosiers
Céline Jaillard
Romain Caplette
Olivier Marre
Stéphane Bertin
Claire-Maelle Fovet
Joanna Demilly
Valérie Forster
Elena Brazhnikova
Philippe Hantraye
Pierre Pouget
Anne Douar
Didier Pruneau
Joël Chavas
José-Alain Sahel
Deniz Dalkara
Jens Duebel
Ryad Benosman
Serge Picaud
author_facet Gregory Gauvain
Himanshu Akolkar
Antoine Chaffiol
Fabrice Arcizet
Mina A. Khoei
Mélissa Desrosiers
Céline Jaillard
Romain Caplette
Olivier Marre
Stéphane Bertin
Claire-Maelle Fovet
Joanna Demilly
Valérie Forster
Elena Brazhnikova
Philippe Hantraye
Pierre Pouget
Anne Douar
Didier Pruneau
Joël Chavas
José-Alain Sahel
Deniz Dalkara
Jens Duebel
Ryad Benosman
Serge Picaud
author_sort Gregory Gauvain
title Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
title_short Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
title_full Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
title_fullStr Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
title_full_unstemmed Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
title_sort optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0b4ca90d06f64da69afaff7c49d68f90
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