Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance.

Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of the drug(s). Thus, inhibiting P-gp expression mi...

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Autores principales: Yan Xu, Stephen J Ohms, Zhen Li, Qiao Wang, Guangming Gong, Yiqiao Hu, Zhiyong Mao, M Frances Shannon, Jun Y Fan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/0b4cf90000bb4aa59dee0a38ea518788
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