Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up

Background: Post-acute COVID-19 syndrome (PACS) is an emerging healthcare burden. We therefore aimed to determine predictors of different functional outcomes after hospital discharge in patients with COVID-19. Methods: An ambidirectional cohort study was conducted between May and July 2020, in which...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Imad M. Tleyjeh, Basema Saddik, Rakhee K. Ramakrishnan, Nourah AlSwaidan, Ahmed AlAnazi, Deema Alhazmi, Ahmad Aloufi, Fahad AlSumait, Elie F. Berbari, Rabih Halwani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Post-acute COVID-19 syndrome PACS Long COVID Breathlessness Exercise intolerance Chronic fatigue Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0b4d8ea47ef7408ea01029305aa7e2d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0b4d8ea47ef7408ea01029305aa7e2d5
record_format	dspace
spelling	oai:doaj.org-article:0b4d8ea47ef7408ea01029305aa7e2d52021-12-02T05:00:20ZLong term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up1876-034110.1016/j.jiph.2021.11.016https://doaj.org/article/0b4d8ea47ef7408ea01029305aa7e2d52022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1876034121003786https://doaj.org/toc/1876-0341Background: Post-acute COVID-19 syndrome (PACS) is an emerging healthcare burden. We therefore aimed to determine predictors of different functional outcomes after hospital discharge in patients with COVID-19. Methods: An ambidirectional cohort study was conducted between May and July 2020, in which PCR-confirmed COVID-19 patients underwent a standardized telephone assessment between 6 weeks and 6 months post discharge. We excluded patients who died, had a mental illness or failed to respond to two follow-up phone calls. The medical research council (MRC) dyspnea scale, metabolic equivalent of task (MET) score for exercise tolerance, chronic fatigability syndrome (CFS) scale and World Health Organization-five well-being index (WHO-5) for mental health were used to evaluate symptoms at follow-up. Results: 375 patients were contacted and 153 failed to respond. The median timing for the follow-up assessment was 122 days (IQR, 109–158). On multivariate analyses, female gender, pre-existing lung disease, headache at presentation, intensive care unit (ICU) admission, critical COVID-19 and post-discharge ER visit were predictors of higher MRC scores at follow-up. Female gender, older age >67 years, arterial hypertension and emergency room (ER) visit were associated with lower MET exercise tolerance scores. Female gender, pre-existing lung disease, and ER visit were associated with higher risk of CFS. Age, dyslipidemia, hypertension, pre-existing lung disease and duration of symptoms were negatively associated with WHO-5 score. Conclusions: Several risk factors were associated with an increased risk of PACS. Hospitalized patients with COVID-19 who are at risk for PACS may benefit from a targeted pre-emptive follow-up and rehabilitation programs.Imad M. TleyjehBasema SaddikRakhee K. RamakrishnanNourah AlSwaidanAhmed AlAnaziDeema AlhazmiAhmad AloufiFahad AlSumaitElie F. BerbariRabih HalwaniElsevierarticlePost-acute COVID-19 syndromePACSLong COVIDBreathlessnessExercise intoleranceChronic fatigueInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENJournal of Infection and Public Health, Vol 15, Iss 1, Pp 21-28 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Post-acute COVID-19 syndrome PACS Long COVID Breathlessness Exercise intolerance Chronic fatigue Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Post-acute COVID-19 syndrome PACS Long COVID Breathlessness Exercise intolerance Chronic fatigue Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Imad M. Tleyjeh Basema Saddik Rakhee K. Ramakrishnan Nourah AlSwaidan Ahmed AlAnazi Deema Alhazmi Ahmad Aloufi Fahad AlSumait Elie F. Berbari Rabih Halwani Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
description	Background: Post-acute COVID-19 syndrome (PACS) is an emerging healthcare burden. We therefore aimed to determine predictors of different functional outcomes after hospital discharge in patients with COVID-19. Methods: An ambidirectional cohort study was conducted between May and July 2020, in which PCR-confirmed COVID-19 patients underwent a standardized telephone assessment between 6 weeks and 6 months post discharge. We excluded patients who died, had a mental illness or failed to respond to two follow-up phone calls. The medical research council (MRC) dyspnea scale, metabolic equivalent of task (MET) score for exercise tolerance, chronic fatigability syndrome (CFS) scale and World Health Organization-five well-being index (WHO-5) for mental health were used to evaluate symptoms at follow-up. Results: 375 patients were contacted and 153 failed to respond. The median timing for the follow-up assessment was 122 days (IQR, 109–158). On multivariate analyses, female gender, pre-existing lung disease, headache at presentation, intensive care unit (ICU) admission, critical COVID-19 and post-discharge ER visit were predictors of higher MRC scores at follow-up. Female gender, older age >67 years, arterial hypertension and emergency room (ER) visit were associated with lower MET exercise tolerance scores. Female gender, pre-existing lung disease, and ER visit were associated with higher risk of CFS. Age, dyslipidemia, hypertension, pre-existing lung disease and duration of symptoms were negatively associated with WHO-5 score. Conclusions: Several risk factors were associated with an increased risk of PACS. Hospitalized patients with COVID-19 who are at risk for PACS may benefit from a targeted pre-emptive follow-up and rehabilitation programs.
format	article
author	Imad M. Tleyjeh Basema Saddik Rakhee K. Ramakrishnan Nourah AlSwaidan Ahmed AlAnazi Deema Alhazmi Ahmad Aloufi Fahad AlSumait Elie F. Berbari Rabih Halwani
author_facet	Imad M. Tleyjeh Basema Saddik Rakhee K. Ramakrishnan Nourah AlSwaidan Ahmed AlAnazi Deema Alhazmi Ahmad Aloufi Fahad AlSumait Elie F. Berbari Rabih Halwani
author_sort	Imad M. Tleyjeh
title	Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
title_short	Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
title_full	Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
title_fullStr	Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
title_full_unstemmed	Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up
title_sort	long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with covid-19: a cohort study with 4 months median follow-up
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/0b4d8ea47ef7408ea01029305aa7e2d5
work_keys_str_mv	AT imadmtleyjeh longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT basemasaddik longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT rakheekramakrishnan longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT nourahalswaidan longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT ahmedalanazi longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT deemaalhazmi longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT ahmadaloufi longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT fahadalsumait longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT eliefberbari longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup AT rabihhalwani longtermpredictorsofbreathlessnessexerciseintolerancechronicfatigueandwellbeinginhospitalizedpatientswithcovid19acohortstudywith4monthsmedianfollowup
_version_	1718400811929698304

Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up

Ejemplares similares