APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing...

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Autores principales:	Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b522666697f4ba891fb72be5cba002f
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spelling	oai:doaj.org-article:0b522666697f4ba891fb72be5cba002f2021-12-02T14:40:30ZAPOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy10.1038/s41467-020-14568-72041-1723https://doaj.org/article/0b522666697f4ba891fb72be5cba002f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14568-7https://doaj.org/toc/2041-1723DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy.Christopher B. DriscollMatthew R. SchuelkeTimothy KottkeJill M. ThompsonPhonphimon WongthidaJason M. TonneAmanda L. HuffAmber MillerKevin G. ShimAmy MolanCynthia WetmorePeter SelbyAdel SamsonKevin HarringtonHardev PandhaAlan MelcherJose S. PulidoReuben HarrisLaura EvginRichard G. VileNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
description	DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy.
format	article
author	Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile
author_facet	Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile
author_sort	Christopher B. Driscoll
title	APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
title_short	APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
title_full	APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
title_fullStr	APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
title_full_unstemmed	APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
title_sort	apobec3b-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0b522666697f4ba891fb72be5cba002f
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APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

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