Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic

Aim. Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19. Materials and methods. A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain...

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Autores principales:	Oleg O. Ianushevich, Igor V. Maev, Natella I. Krikheli, Oleg V. Levchenko, Irina V. Rogova, Andrei V. Zaborovskii, Dmitrii N. Andreev, Anastasiia L. Kebina, Dmitrii S. Bordin, Igor G. Bakulin, Natalia V. Bakulina, Nikolai G. Andreev, Pavel O. Asadulin, Armine S. Bagdasarian, Mikhail K. Devkota, Natalia R. Evarnitskaia, Olga V. Krikunova, Sergei A. Kucher, Filip S. Sokolov, Aleksei K. Fomenko, Vadim A. Khar'kovskii, Irina A. Sharina
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	coronavirus covid-19 sars-cov-2 gastrointestinal tract diarrhea nausea vomiting abdominal pain Medicine R
Acceso en línea:	https://doaj.org/article/0b5274c906554cd2ba9f2df6ed258568
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spelling	oai:doaj.org-article:0b5274c906554cd2ba9f2df6ed2585682021-12-01T12:22:36ZPrevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic0040-36602309-534210.26442/00403660.2021.08.200977https://doaj.org/article/0b5274c906554cd2ba9f2df6ed2585682021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79412/60064https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Aim. Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19. Materials and methods. A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain reaction in oro-/nasopharyngeal smear samples were subject to analysis. Patients with documented (according to anamnestic data and/or according to examination data during hospitalization) organic pathology of the gastrointestinal tract (GIT) and/or hepatobiliary system, malignant neoplasms of any localization, as well as pregnant patients were excluded from the general register of retrospective data. The final cohort was divided into two groups depending on the presence of gastrointestinal symptoms: COVID-19 with gastrointestinal symptoms (cases) and COVID-19 without gastrointestinal symptoms (control). Results. The final sample consisted of 3764 patients, including 2108 (56%) women and 1656 (44%) men. The average age of the subjects included in the analysis was 58.0 years (95% confidence interval CI 48.663.0). In the study cohort, gastroenterological manifestations (alone or in combination) were recorded in 885 (23.51%) patients. Calculation of the odds ratio (OR) of unfavorable and lethal outcomes between the analyzed groups showed that the presence of gastroenterological symptoms significantly increases the chances of lethal outcome in a cohort of elderly and senile patients (OR 1.6817, 95% CI 1.03352.7364; p=0.0364), determines a higher risk of hospitalization or transfer to the intensive care unit (OR 1.2959, 95% CI 1.05471.5922; p=0.0136), development of acute respiratory distress syndrome (OR 1.5952, 95% CI 1.31641.9329; p0.0001), as well as the need for mechanical ventilation (OR 1.2849, 95% CI 1.0771.5329; p=0.0054). Conclusion. The present study has demonstrated that gastroenterological symptoms are detected in about one in four patients infected with the SARS-CoV-2 virus and multiply the risk of adverse and life-threatening complications of COVID-19.Oleg O. IanushevichIgor V. MaevNatella I. KrikheliOleg V. LevchenkoIrina V. RogovaAndrei V. ZaborovskiiDmitrii N. AndreevAnastasiia L. KebinaDmitrii S. BordinIgor G. BakulinNatalia V. BakulinaNikolai G. AndreevPavel O. AsadulinArmine S. BagdasarianMikhail K. DevkotaNatalia R. EvarnitskaiaOlga V. KrikunovaSergei A. KucherFilip S. SokolovAleksei K. FomenkoVadim A. Khar'kovskiiIrina A. Sharina"Consilium Medicum" Publishing housearticlecoronaviruscovid-19sars-cov-2gastrointestinal tractdiarrheanauseavomitingabdominal painMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 853-861 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	coronavirus covid-19 sars-cov-2 gastrointestinal tract diarrhea nausea vomiting abdominal pain Medicine R
spellingShingle	coronavirus covid-19 sars-cov-2 gastrointestinal tract diarrhea nausea vomiting abdominal pain Medicine R Oleg O. Ianushevich Igor V. Maev Natella I. Krikheli Oleg V. Levchenko Irina V. Rogova Andrei V. Zaborovskii Dmitrii N. Andreev Anastasiia L. Kebina Dmitrii S. Bordin Igor G. Bakulin Natalia V. Bakulina Nikolai G. Andreev Pavel O. Asadulin Armine S. Bagdasarian Mikhail K. Devkota Natalia R. Evarnitskaia Olga V. Krikunova Sergei A. Kucher Filip S. Sokolov Aleksei K. Fomenko Vadim A. Khar'kovskii Irina A. Sharina Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
description	Aim. Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19. Materials and methods. A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain reaction in oro-/nasopharyngeal smear samples were subject to analysis. Patients with documented (according to anamnestic data and/or according to examination data during hospitalization) organic pathology of the gastrointestinal tract (GIT) and/or hepatobiliary system, malignant neoplasms of any localization, as well as pregnant patients were excluded from the general register of retrospective data. The final cohort was divided into two groups depending on the presence of gastrointestinal symptoms: COVID-19 with gastrointestinal symptoms (cases) and COVID-19 without gastrointestinal symptoms (control). Results. The final sample consisted of 3764 patients, including 2108 (56%) women and 1656 (44%) men. The average age of the subjects included in the analysis was 58.0 years (95% confidence interval CI 48.663.0). In the study cohort, gastroenterological manifestations (alone or in combination) were recorded in 885 (23.51%) patients. Calculation of the odds ratio (OR) of unfavorable and lethal outcomes between the analyzed groups showed that the presence of gastroenterological symptoms significantly increases the chances of lethal outcome in a cohort of elderly and senile patients (OR 1.6817, 95% CI 1.03352.7364; p=0.0364), determines a higher risk of hospitalization or transfer to the intensive care unit (OR 1.2959, 95% CI 1.05471.5922; p=0.0136), development of acute respiratory distress syndrome (OR 1.5952, 95% CI 1.31641.9329; p0.0001), as well as the need for mechanical ventilation (OR 1.2849, 95% CI 1.0771.5329; p=0.0054). Conclusion. The present study has demonstrated that gastroenterological symptoms are detected in about one in four patients infected with the SARS-CoV-2 virus and multiply the risk of adverse and life-threatening complications of COVID-19.
format	article
author	Oleg O. Ianushevich Igor V. Maev Natella I. Krikheli Oleg V. Levchenko Irina V. Rogova Andrei V. Zaborovskii Dmitrii N. Andreev Anastasiia L. Kebina Dmitrii S. Bordin Igor G. Bakulin Natalia V. Bakulina Nikolai G. Andreev Pavel O. Asadulin Armine S. Bagdasarian Mikhail K. Devkota Natalia R. Evarnitskaia Olga V. Krikunova Sergei A. Kucher Filip S. Sokolov Aleksei K. Fomenko Vadim A. Khar'kovskii Irina A. Sharina
author_facet	Oleg O. Ianushevich Igor V. Maev Natella I. Krikheli Oleg V. Levchenko Irina V. Rogova Andrei V. Zaborovskii Dmitrii N. Andreev Anastasiia L. Kebina Dmitrii S. Bordin Igor G. Bakulin Natalia V. Bakulina Nikolai G. Andreev Pavel O. Asadulin Armine S. Bagdasarian Mikhail K. Devkota Natalia R. Evarnitskaia Olga V. Krikunova Sergei A. Kucher Filip S. Sokolov Aleksei K. Fomenko Vadim A. Khar'kovskii Irina A. Sharina
author_sort	Oleg O. Ianushevich
title	Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
title_short	Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
title_full	Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
title_fullStr	Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
title_full_unstemmed	Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
title_sort	prevalence and prognostic value of gastroenterological manifestations of covid-19: data from the russian university clinic
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/0b5274c906554cd2ba9f2df6ed258568
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Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic

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