Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy

Abstract There are no clinical interventions to prevent post-injury epilepsy, a common and devastating outcome after brain insults. Epileptogenic events that run from brain injury to epilepsy are poorly understood. Previous studies in our laboratory suggested Proechimys, an exotic Amazonian rodent,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nancy N. Ortiz-Villatoro, Selvin Z. Reyes-Garcia, Leandro Freitas, Laís D. Rodrigues, Luiz E. C. Santos, Jean Faber, Esper A. Cavalheiro, Josef Finsterer, Fulvio A. Scorza, Antônio C. G. de Almeida, Carla A. Scorza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b52ce39a1b647888fee371b3f60fa81
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0b52ce39a1b647888fee371b3f60fa81
record_format	dspace
spelling	oai:doaj.org-article:0b52ce39a1b647888fee371b3f60fa812021-12-02T17:08:35ZAmazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy10.1038/s41598-021-96235-52045-2322https://doaj.org/article/0b52ce39a1b647888fee371b3f60fa812021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96235-5https://doaj.org/toc/2045-2322Abstract There are no clinical interventions to prevent post-injury epilepsy, a common and devastating outcome after brain insults. Epileptogenic events that run from brain injury to epilepsy are poorly understood. Previous studies in our laboratory suggested Proechimys, an exotic Amazonian rodent, as resistant to acquired epilepsy development in post-status epilepticus models. The present comparative study was conducted to assess (1) stroke-related brain responses 24-h and 30 days after cortical photothrombosis and (2) post-stroke epilepsy between Proechimys rodents and Wistar rats, a traditional animal used for laboratory research. Proechimys group showed smaller volume of ischemic infarction and lesser glial activation than Wistar group. In contrast to Wistar rats, post-stroke decreased levels of pro-inflammatory cytokines and increased levels of anti-inflammatory mediators and growth factors were found in Proechimys. Electrophysiological signaling changes assessed by cortical spreading depression, in vitro and in vivo, showed that Wistar’s brain is most severely affected by stroke. Chronic electrocorticographic recordings showed that injury did not lead to epilepsy in Proechimys whereas 88% of the Wistar rats developed post-stroke epilepsy. Science gains insights from comparative studies on diverse species. Proechimys rodents proved to be a useful animal model to study antiepileptogenic mechanisms after brain insults and complement conventional animal models.Nancy N. Ortiz-VillatoroSelvin Z. Reyes-GarciaLeandro FreitasLaís D. RodriguesLuiz E. C. SantosJean FaberEsper A. CavalheiroJosef FinstererFulvio A. ScorzaAntônio C. G. de AlmeidaCarla A. ScorzaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nancy N. Ortiz-Villatoro Selvin Z. Reyes-Garcia Leandro Freitas Laís D. Rodrigues Luiz E. C. Santos Jean Faber Esper A. Cavalheiro Josef Finsterer Fulvio A. Scorza Antônio C. G. de Almeida Carla A. Scorza Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
description	Abstract There are no clinical interventions to prevent post-injury epilepsy, a common and devastating outcome after brain insults. Epileptogenic events that run from brain injury to epilepsy are poorly understood. Previous studies in our laboratory suggested Proechimys, an exotic Amazonian rodent, as resistant to acquired epilepsy development in post-status epilepticus models. The present comparative study was conducted to assess (1) stroke-related brain responses 24-h and 30 days after cortical photothrombosis and (2) post-stroke epilepsy between Proechimys rodents and Wistar rats, a traditional animal used for laboratory research. Proechimys group showed smaller volume of ischemic infarction and lesser glial activation than Wistar group. In contrast to Wistar rats, post-stroke decreased levels of pro-inflammatory cytokines and increased levels of anti-inflammatory mediators and growth factors were found in Proechimys. Electrophysiological signaling changes assessed by cortical spreading depression, in vitro and in vivo, showed that Wistar’s brain is most severely affected by stroke. Chronic electrocorticographic recordings showed that injury did not lead to epilepsy in Proechimys whereas 88% of the Wistar rats developed post-stroke epilepsy. Science gains insights from comparative studies on diverse species. Proechimys rodents proved to be a useful animal model to study antiepileptogenic mechanisms after brain insults and complement conventional animal models.
format	article
author	Nancy N. Ortiz-Villatoro Selvin Z. Reyes-Garcia Leandro Freitas Laís D. Rodrigues Luiz E. C. Santos Jean Faber Esper A. Cavalheiro Josef Finsterer Fulvio A. Scorza Antônio C. G. de Almeida Carla A. Scorza
author_facet	Nancy N. Ortiz-Villatoro Selvin Z. Reyes-Garcia Leandro Freitas Laís D. Rodrigues Luiz E. C. Santos Jean Faber Esper A. Cavalheiro Josef Finsterer Fulvio A. Scorza Antônio C. G. de Almeida Carla A. Scorza
author_sort	Nancy N. Ortiz-Villatoro
title	Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
title_short	Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
title_full	Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
title_fullStr	Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
title_full_unstemmed	Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
title_sort	amazon rainforest rodents (proechimys) are resistant to post-stroke epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0b52ce39a1b647888fee371b3f60fa81
work_keys_str_mv	AT nancynortizvillatoro amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT selvinzreyesgarcia amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT leandrofreitas amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT laisdrodrigues amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT luizecsantos amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT jeanfaber amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT esperacavalheiro amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT joseffinsterer amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT fulvioascorza amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT antoniocgdealmeida amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy AT carlaascorza amazonrainforestrodentsproechimysareresistanttopoststrokeepilepsy
_version_	1718381537898004480

Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy

Ejemplares similares