Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

<h4>Introduction</h4>Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture...

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Autores principales: Stuart J Smith, Martin Wilson, Jennifer H Ward, Cheryl V Rahman, Andrew C Peet, Donald C Macarthur, Felicity R A J Rose, Richard G Grundy, Ruman Rahman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/0b5326e51f734aaabbbf930afbebf33f
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