BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination
BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential for mouse meiosis.
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Nature Portfolio
2021
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oai:doaj.org-article:0b53e0fe0b894a1fac23825f31a884062021-12-02T16:24:23ZBRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination10.1038/s41467-021-24871-62041-1723https://doaj.org/article/0b53e0fe0b894a1fac23825f31a884062021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24871-6https://doaj.org/toc/2041-1723BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential for mouse meiosis.Rania GhouilSimona MironLieke KoornneefJasper VeermanMaarten W. PaulMarie-Hélène Le DuEsther Sleddens-LinkelsSari E. van Rossum-FikkertYvette van LoonNatalia Felipe-MedinaAlberto M. PendasAlex MaasJeroen EssersPierre LegrandWilly M. BaarendsRoland KanaarSophie Zinn-JustinAlex N. ZelenskyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Rania Ghouil Simona Miron Lieke Koornneef Jasper Veerman Maarten W. Paul Marie-Hélène Le Du Esther Sleddens-Linkels Sari E. van Rossum-Fikkert Yvette van Loon Natalia Felipe-Medina Alberto M. Pendas Alex Maas Jeroen Essers Pierre Legrand Willy M. Baarends Roland Kanaar Sophie Zinn-Justin Alex N. Zelensky BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| description |
BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential for mouse meiosis. |
| format |
article |
| author |
Rania Ghouil Simona Miron Lieke Koornneef Jasper Veerman Maarten W. Paul Marie-Hélène Le Du Esther Sleddens-Linkels Sari E. van Rossum-Fikkert Yvette van Loon Natalia Felipe-Medina Alberto M. Pendas Alex Maas Jeroen Essers Pierre Legrand Willy M. Baarends Roland Kanaar Sophie Zinn-Justin Alex N. Zelensky |
| author_facet |
Rania Ghouil Simona Miron Lieke Koornneef Jasper Veerman Maarten W. Paul Marie-Hélène Le Du Esther Sleddens-Linkels Sari E. van Rossum-Fikkert Yvette van Loon Natalia Felipe-Medina Alberto M. Pendas Alex Maas Jeroen Essers Pierre Legrand Willy M. Baarends Roland Kanaar Sophie Zinn-Justin Alex N. Zelensky |
| author_sort |
Rania Ghouil |
| title |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| title_short |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| title_full |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| title_fullStr |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| title_full_unstemmed |
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination |
| title_sort |
brca2 binding through a cryptic repeated motif to hsf2bp oligomers does not impact meiotic recombination |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0b53e0fe0b894a1fac23825f31a88406 |
| work_keys_str_mv |
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| _version_ |
1718384094049468416 |