Lipid order and charge protect killer T cells from accidental death

Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes). Here authors show that two mechanisms protect the membranes of CTLs from disruption by perforin and granzymes.

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Autores principales:	Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b570a4b9b4f425cbf44500be5992740
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spelling	oai:doaj.org-article:0b570a4b9b4f425cbf44500be59927402021-12-02T17:01:59ZLipid order and charge protect killer T cells from accidental death10.1038/s41467-019-13385-x2041-1723https://doaj.org/article/0b570a4b9b4f425cbf44500be59927402019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13385-xhttps://doaj.org/toc/2041-1723Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes). Here authors show that two mechanisms protect the membranes of CTLs from disruption by perforin and granzymes.Jesse A. Rudd-SchmidtAdrian W. HodelTahereh NooriJamie A. LopezHyun-Jung ChoSandra VerschoorAnnette CicconeJoseph A. TrapaniBart W. HoogenboomIlia VoskoboinikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesse A. Rudd-Schmidt Adrian W. Hodel Tahereh Noori Jamie A. Lopez Hyun-Jung Cho Sandra Verschoor Annette Ciccone Joseph A. Trapani Bart W. Hoogenboom Ilia Voskoboinik Lipid order and charge protect killer T cells from accidental death
description	Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore-forming protein (perforin) and pro-apoptotic serine proteases (granzymes). Here authors show that two mechanisms protect the membranes of CTLs from disruption by perforin and granzymes.
format	article
author	Jesse A. Rudd-Schmidt Adrian W. Hodel Tahereh Noori Jamie A. Lopez Hyun-Jung Cho Sandra Verschoor Annette Ciccone Joseph A. Trapani Bart W. Hoogenboom Ilia Voskoboinik
author_facet	Jesse A. Rudd-Schmidt Adrian W. Hodel Tahereh Noori Jamie A. Lopez Hyun-Jung Cho Sandra Verschoor Annette Ciccone Joseph A. Trapani Bart W. Hoogenboom Ilia Voskoboinik
author_sort	Jesse A. Rudd-Schmidt
title	Lipid order and charge protect killer T cells from accidental death
title_short	Lipid order and charge protect killer T cells from accidental death
title_full	Lipid order and charge protect killer T cells from accidental death
title_fullStr	Lipid order and charge protect killer T cells from accidental death
title_full_unstemmed	Lipid order and charge protect killer T cells from accidental death
title_sort	lipid order and charge protect killer t cells from accidental death
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0b570a4b9b4f425cbf44500be5992740
work_keys_str_mv	AT jessearuddschmidt lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT adrianwhodel lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT taherehnoori lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT jamiealopez lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT hyunjungcho lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT sandraverschoor lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT annetteciccone lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT josephatrapani lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT bartwhoogenboom lipidorderandchargeprotectkillertcellsfromaccidentaldeath AT iliavoskoboinik lipidorderandchargeprotectkillertcellsfromaccidentaldeath
_version_	1718381949556359168

Lipid order and charge protect killer T cells from accidental death

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