THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS

Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lowe...

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Autores principales:	D. S. Baranova, L. V. Sakhno, I. V. Kruchkova, N. V. Pronkina, M. A. Tikhonova, E. V. Batorov, A. V. Gilevich, V. V. Sergeyevicheva, S. A. Sizikova, G. Yu. Ushakova, A. A. Ostanin, T. I. Pospelova, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	autologous hematopoietic stem cell transplantation apheresis product Science Q
Acceso en línea:	https://doaj.org/article/0b5909017ef04dd4ad736063d8431e4a
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spelling	oai:doaj.org-article:0b5909017ef04dd4ad736063d8431e4a2021-11-23T06:14:19ZTHE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS2541-94202587-9596https://doaj.org/article/0b5909017ef04dd4ad736063d8431e4a2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/879https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lower counts of granulocytes. Significant increase of relative numbers of dividing CD34+ cells (in S, G2/M phases of the cell cycle) was demonstrated, in acute leucosis patients' grafts. In lymphoma grafts the levels of CD34+ cells in G0/G1 phases were found, to be increased. Cells isolated from grafts of acute leucosis patients characterized by higher levels of proinflammatory cytokines production, such as IL-1, IL-6, MIP-1β, TNF-α, IL-8, IFN-γ (the last two ones— non-significant trend) and cytokines, essential for humoral immune response (IL-4 and — in trend — IL-10). The existing differences didn't influence on effectiveness of early lymphocyte recovery.D. S. BaranovaL. V. SakhnoI. V. KruchkovaN. V. PronkinaM. A. TikhonovaE. V. BatorovA. V. GilevichV. V. SergeyevichevaS. A. SizikovaG. Yu. UshakovaA. A. OstaninT. I. PospelovaE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticleautologous hematopoietic stem cell transplantationapheresis productScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 29-32 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	autologous hematopoietic stem cell transplantation apheresis product Science Q
spellingShingle	autologous hematopoietic stem cell transplantation apheresis product Science Q D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
description	Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lower counts of granulocytes. Significant increase of relative numbers of dividing CD34+ cells (in S, G2/M phases of the cell cycle) was demonstrated, in acute leucosis patients' grafts. In lymphoma grafts the levels of CD34+ cells in G0/G1 phases were found, to be increased. Cells isolated from grafts of acute leucosis patients characterized by higher levels of proinflammatory cytokines production, such as IL-1, IL-6, MIP-1β, TNF-α, IL-8, IFN-γ (the last two ones— non-significant trend) and cytokines, essential for humoral immune response (IL-4 and — in trend — IL-10). The existing differences didn't influence on effectiveness of early lymphocyte recovery.
format	article
author	D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh
author_facet	D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh
author_sort	D. S. Baranova
title	THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
title_short	THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
title_full	THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
title_fullStr	THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
title_full_unstemmed	THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
title_sort	comparative analysis of graft cell subtypes and its cytokine production of lymphoma and leucosis patients
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/0b5909017ef04dd4ad736063d8431e4a
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THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS

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