Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.

<h4>Purpose</h4>To investigate the dynamics of the healing process after therapeutic subthreshold micropulse laser (SMPL) for diabetic macular edema (DME) using polarization-sensitive optical coherence tomography (PS-OCT).<h4>Methods</h4>Patients with treatment-native or prev...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koji Ueda, Tomoyasu Shiraya, Fumiyuki Araki, Yohei Hashimoto, Motoshi Yamamoto, Masahiro Yamanari, Takashi Ueta, Takahiro Minami, Nobuyori Aoki, Satoshi Sugiyama, Han Peng Zhou, Kiyohito Totsuka, Taku Toyama, Koichiro Sugimoto, Ryo Obata, Satoshi Kato
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b5b6207847348af83adef252f0ae46d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0b5b6207847348af83adef252f0ae46d
record_format	dspace
spelling	oai:doaj.org-article:0b5b6207847348af83adef252f0ae46d2021-12-02T20:14:40ZChanges in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.1932-620310.1371/journal.pone.0257000https://doaj.org/article/0b5b6207847348af83adef252f0ae46d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257000https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the dynamics of the healing process after therapeutic subthreshold micropulse laser (SMPL) for diabetic macular edema (DME) using polarization-sensitive optical coherence tomography (PS-OCT).<h4>Methods</h4>Patients with treatment-native or previously-treated DME were prospectively imaged using PS-OCT at baseline, 1, 2, 3, and 6 months. The following outcomes were evaluated: changes in the entropy value per unit area (pixel2) in the retinal pigment epithelium (RPE) on the B-scan image; changes in the entropy value in each stratified layer (retina, RPE, choroid) based on the ETDRS grid circle overlaid with en face entropy mapping, not only the whole ETDRS grid area but also a sector irradiated by the SMPL; and the relationship between edema reduction and entropy changes.<h4>Results</h4>A total of 11 eyes of 11 consecutive DME patients were enrolled. No visible signs of SMPL treatment were detected on PS-OCT images. The entropy value per unit area (pixel2) in the RPE tended to decrease at 3 and 6 months from baseline (35.8 ± 17.0 vs 26.1 ± 9.8, P = 0.14; vs 28.2 ± 18.3, P = 0.14). Based on the en face entropy mapping, the overall entropy value did not change in each layer in the whole ETDRS grid; however, decrease of entropy in the RPE was observed at 2, 3, and 6 months post-treatment within the SMPL-irradiated sectors (P < 0.01, each). There was a positive correlation between the change rate of retinal thickness and that of entropy in the RPE within the SMPL-irradiated sector at 6 months (r2 = 0.19, P = 0.039).<h4>Conclusion</h4>Entropy measured using PS-OCT may be a new parameter that facilitates objective monitoring of SMPL-induced functional changes in the RPE that could not previously be assessed directly. This may contribute to a more promising therapeutic evaluation of DME.<h4>Clinical trial</h4>This clinical study was registered in UMIN-CTR (ID: UMIN000042420).Koji UedaTomoyasu ShirayaFumiyuki ArakiYohei HashimotoMotoshi YamamotoMasahiro YamanariTakashi UetaTakahiro MinamiNobuyori AokiSatoshi SugiyamaHan Peng ZhouKiyohito TotsukaTaku ToyamaKoichiro SugimotoRyo ObataSatoshi KatoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257000 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koji Ueda Tomoyasu Shiraya Fumiyuki Araki Yohei Hashimoto Motoshi Yamamoto Masahiro Yamanari Takashi Ueta Takahiro Minami Nobuyori Aoki Satoshi Sugiyama Han Peng Zhou Kiyohito Totsuka Taku Toyama Koichiro Sugimoto Ryo Obata Satoshi Kato Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
description	<h4>Purpose</h4>To investigate the dynamics of the healing process after therapeutic subthreshold micropulse laser (SMPL) for diabetic macular edema (DME) using polarization-sensitive optical coherence tomography (PS-OCT).<h4>Methods</h4>Patients with treatment-native or previously-treated DME were prospectively imaged using PS-OCT at baseline, 1, 2, 3, and 6 months. The following outcomes were evaluated: changes in the entropy value per unit area (pixel2) in the retinal pigment epithelium (RPE) on the B-scan image; changes in the entropy value in each stratified layer (retina, RPE, choroid) based on the ETDRS grid circle overlaid with en face entropy mapping, not only the whole ETDRS grid area but also a sector irradiated by the SMPL; and the relationship between edema reduction and entropy changes.<h4>Results</h4>A total of 11 eyes of 11 consecutive DME patients were enrolled. No visible signs of SMPL treatment were detected on PS-OCT images. The entropy value per unit area (pixel2) in the RPE tended to decrease at 3 and 6 months from baseline (35.8 ± 17.0 vs 26.1 ± 9.8, P = 0.14; vs 28.2 ± 18.3, P = 0.14). Based on the en face entropy mapping, the overall entropy value did not change in each layer in the whole ETDRS grid; however, decrease of entropy in the RPE was observed at 2, 3, and 6 months post-treatment within the SMPL-irradiated sectors (P < 0.01, each). There was a positive correlation between the change rate of retinal thickness and that of entropy in the RPE within the SMPL-irradiated sector at 6 months (r2 = 0.19, P = 0.039).<h4>Conclusion</h4>Entropy measured using PS-OCT may be a new parameter that facilitates objective monitoring of SMPL-induced functional changes in the RPE that could not previously be assessed directly. This may contribute to a more promising therapeutic evaluation of DME.<h4>Clinical trial</h4>This clinical study was registered in UMIN-CTR (ID: UMIN000042420).
format	article
author	Koji Ueda Tomoyasu Shiraya Fumiyuki Araki Yohei Hashimoto Motoshi Yamamoto Masahiro Yamanari Takashi Ueta Takahiro Minami Nobuyori Aoki Satoshi Sugiyama Han Peng Zhou Kiyohito Totsuka Taku Toyama Koichiro Sugimoto Ryo Obata Satoshi Kato
author_facet	Koji Ueda Tomoyasu Shiraya Fumiyuki Araki Yohei Hashimoto Motoshi Yamamoto Masahiro Yamanari Takashi Ueta Takahiro Minami Nobuyori Aoki Satoshi Sugiyama Han Peng Zhou Kiyohito Totsuka Taku Toyama Koichiro Sugimoto Ryo Obata Satoshi Kato
author_sort	Koji Ueda
title	Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
title_short	Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
title_full	Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
title_fullStr	Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
title_full_unstemmed	Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.
title_sort	changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: a pilot study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0b5b6207847348af83adef252f0ae46d
work_keys_str_mv	AT kojiueda changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT tomoyasushiraya changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT fumiyukiaraki changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT yoheihashimoto changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT motoshiyamamoto changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT masahiroyamanari changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT takashiueta changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT takahirominami changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT nobuyoriaoki changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT satoshisugiyama changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT hanpengzhou changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT kiyohitototsuka changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT takutoyama changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT koichirosugimoto changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT ryoobata changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy AT satoshikato changesinentropyonpolarizedsensitiveopticalcoherencetomographyimagesaftertherapeuticsubthresholdmicropulselaserfordiabeticmacularedemaapilotstudy
_version_	1718374627858710528

Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.

Ejemplares similares