Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.

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Autores principales: Mélanie Gracia, Sophie Theis, Amsha Proag, Guillaume Gay, Corinne Benassayag, Magali Suzanne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0b5e52f5c518423d9d99a13ba0e0739d
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spelling oai:doaj.org-article:0b5e52f5c518423d9d99a13ba0e0739d2021-12-02T16:57:34ZMechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila10.1038/s41467-019-10720-02041-1723https://doaj.org/article/0b5e52f5c518423d9d99a13ba0e0739d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10720-0https://doaj.org/toc/2041-1723Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.Mélanie GraciaSophie TheisAmsha ProagGuillaume GayCorinne BenassayagMagali SuzanneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mélanie Gracia
Sophie Theis
Amsha Proag
Guillaume Gay
Corinne Benassayag
Magali Suzanne
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
description Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.
format article
author Mélanie Gracia
Sophie Theis
Amsha Proag
Guillaume Gay
Corinne Benassayag
Magali Suzanne
author_facet Mélanie Gracia
Sophie Theis
Amsha Proag
Guillaume Gay
Corinne Benassayag
Magali Suzanne
author_sort Mélanie Gracia
title Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
title_short Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
title_full Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
title_fullStr Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
title_full_unstemmed Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
title_sort mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in drosophila
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0b5e52f5c518423d9d99a13ba0e0739d
work_keys_str_mv AT melaniegracia mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
AT sophietheis mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
AT amshaproag mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
AT guillaumegay mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
AT corinnebenassayag mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
AT magalisuzanne mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila
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