Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.
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Nature Portfolio
2019
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oai:doaj.org-article:0b5e52f5c518423d9d99a13ba0e0739d2021-12-02T16:57:34ZMechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila10.1038/s41467-019-10720-02041-1723https://doaj.org/article/0b5e52f5c518423d9d99a13ba0e0739d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10720-0https://doaj.org/toc/2041-1723Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.Mélanie GraciaSophie TheisAmsha ProagGuillaume GayCorinne BenassayagMagali SuzanneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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Science Q Mélanie Gracia Sophie Theis Amsha Proag Guillaume Gay Corinne Benassayag Magali Suzanne Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
description |
Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila. |
format |
article |
author |
Mélanie Gracia Sophie Theis Amsha Proag Guillaume Gay Corinne Benassayag Magali Suzanne |
author_facet |
Mélanie Gracia Sophie Theis Amsha Proag Guillaume Gay Corinne Benassayag Magali Suzanne |
author_sort |
Mélanie Gracia |
title |
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
title_short |
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
title_full |
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
title_fullStr |
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
title_full_unstemmed |
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila |
title_sort |
mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in drosophila |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/0b5e52f5c518423d9d99a13ba0e0739d |
work_keys_str_mv |
AT melaniegracia mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila AT sophietheis mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila AT amshaproag mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila AT guillaumegay mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila AT corinnebenassayag mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila AT magalisuzanne mechanicalimpactofepithelialmesenchymaltransitiononepithelialmorphogenesisindrosophila |
_version_ |
1718382486913810432 |