Disrupting upstream translation in mRNAs is associated with human disease

The significance of translated upstream open reading frames is not well known. Here, the authors investigate genetic variants in these regions, finding that they are under high evolutionary constraint and may contribute to disease.

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Autores principales:	David S. M. Lee, Joseph Park, Andrew Kromer, Aris Baras, Daniel J. Rader, Marylyn D. Ritchie, Louis R. Ghanem, Yoseph Barash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b62a6351370456f97407da3d338a006
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spelling	oai:doaj.org-article:0b62a6351370456f97407da3d338a0062021-12-02T13:14:53ZDisrupting upstream translation in mRNAs is associated with human disease10.1038/s41467-021-21812-12041-1723https://doaj.org/article/0b62a6351370456f97407da3d338a0062021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21812-1https://doaj.org/toc/2041-1723The significance of translated upstream open reading frames is not well known. Here, the authors investigate genetic variants in these regions, finding that they are under high evolutionary constraint and may contribute to disease.David S. M. LeeJoseph ParkAndrew KromerAris BarasDaniel J. RaderMarylyn D. RitchieLouis R. GhanemYoseph BarashNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David S. M. Lee Joseph Park Andrew Kromer Aris Baras Daniel J. Rader Marylyn D. Ritchie Louis R. Ghanem Yoseph Barash Disrupting upstream translation in mRNAs is associated with human disease
description	The significance of translated upstream open reading frames is not well known. Here, the authors investigate genetic variants in these regions, finding that they are under high evolutionary constraint and may contribute to disease.
format	article
author	David S. M. Lee Joseph Park Andrew Kromer Aris Baras Daniel J. Rader Marylyn D. Ritchie Louis R. Ghanem Yoseph Barash
author_facet	David S. M. Lee Joseph Park Andrew Kromer Aris Baras Daniel J. Rader Marylyn D. Ritchie Louis R. Ghanem Yoseph Barash
author_sort	David S. M. Lee
title	Disrupting upstream translation in mRNAs is associated with human disease
title_short	Disrupting upstream translation in mRNAs is associated with human disease
title_full	Disrupting upstream translation in mRNAs is associated with human disease
title_fullStr	Disrupting upstream translation in mRNAs is associated with human disease
title_full_unstemmed	Disrupting upstream translation in mRNAs is associated with human disease
title_sort	disrupting upstream translation in mrnas is associated with human disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0b62a6351370456f97407da3d338a006
work_keys_str_mv	AT davidsmlee disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT josephpark disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT andrewkromer disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT arisbaras disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT danieljrader disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT marylyndritchie disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT louisrghanem disruptingupstreamtranslationinmrnasisassociatedwithhumandisease AT yosephbarash disruptingupstreamtranslationinmrnasisassociatedwithhumandisease
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Disrupting upstream translation in mRNAs is associated with human disease

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