Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.

<h4>Background</h4>With the widespread use of broad-spectrum antibiotics, the problem of bacterial resistance has become a global crisis. To monitor bacterial resistance in our hospital, the distribution of specimens, the detection of pathogens and their drug resistance from July 2005 to...

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Autores principales:	Huili Zhang, Kairui Zhou, Xinglong He, Xin Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b6342fe4a044023af9bcf1b14bdf056
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spelling	oai:doaj.org-article:0b6342fe4a044023af9bcf1b14bdf0562021-12-02T20:19:35ZComparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.1932-620310.1371/journal.pone.0256375https://doaj.org/article/0b6342fe4a044023af9bcf1b14bdf0562021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256375https://doaj.org/toc/1932-6203<h4>Background</h4>With the widespread use of broad-spectrum antibiotics, the problem of bacterial resistance has become a global crisis. To monitor bacterial resistance in our hospital, the distribution of specimens, the detection of pathogens and their drug resistance from July 2005 to June 2007 (13 years ago) and July 2018 to June 2020 were compared and analyzed.<h4>Methods</h4>Ordinary specimens (such as sputum, urine, feces, and secretion) were inoculated in blood AGAR media, MacConkey medium, chocolate medium, double SS medium and selective culture medium. Blood, cerebrospinal fluid, pleural effusion, joint cavity effusion and other sterile body fluid samples were inoculated in aerobic and anaerobic blood culture flasks. Automatic microbial identification, drug sensitivity analysis and mass spectrometry analysis were used to determine their drug sensitivity.<h4>Results</h4>Compared with the results obtained 13 years ago, the number of specimens submitted for inspection in the past two years has increased significantly, exhibiting a growth rate of 283%. The changes in the pathogen species were obvious. Gram-positive cocci were the dominant bacteria 13 years ago, and Gram-negative bacilli were the dominant bacteria in the past two years. In addition, the resistance of several major Gram-negative bacilli to piperacillin/tazobactam, cefoperazone/sulbactam, meropenem and imipenem all showed an increasing trend.<h4>Conclusion</h4>The variety of pathogenic bacteria in our hospital has changed significantly in the past two years compared with that 13 years ago, and the clinical isolates of Gram-negative bacilli have increased significantly compared with Gram-positive cocci. In the clinical treatment of anti-infective diseases, antimicrobial agents should be selected according to the bacterial distribution characteristics and drug resistance in each hospital.Huili ZhangKairui ZhouXinglong HeXin YuanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256375 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huili Zhang Kairui Zhou Xinglong He Xin Yuan Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
description	<h4>Background</h4>With the widespread use of broad-spectrum antibiotics, the problem of bacterial resistance has become a global crisis. To monitor bacterial resistance in our hospital, the distribution of specimens, the detection of pathogens and their drug resistance from July 2005 to June 2007 (13 years ago) and July 2018 to June 2020 were compared and analyzed.<h4>Methods</h4>Ordinary specimens (such as sputum, urine, feces, and secretion) were inoculated in blood AGAR media, MacConkey medium, chocolate medium, double SS medium and selective culture medium. Blood, cerebrospinal fluid, pleural effusion, joint cavity effusion and other sterile body fluid samples were inoculated in aerobic and anaerobic blood culture flasks. Automatic microbial identification, drug sensitivity analysis and mass spectrometry analysis were used to determine their drug sensitivity.<h4>Results</h4>Compared with the results obtained 13 years ago, the number of specimens submitted for inspection in the past two years has increased significantly, exhibiting a growth rate of 283%. The changes in the pathogen species were obvious. Gram-positive cocci were the dominant bacteria 13 years ago, and Gram-negative bacilli were the dominant bacteria in the past two years. In addition, the resistance of several major Gram-negative bacilli to piperacillin/tazobactam, cefoperazone/sulbactam, meropenem and imipenem all showed an increasing trend.<h4>Conclusion</h4>The variety of pathogenic bacteria in our hospital has changed significantly in the past two years compared with that 13 years ago, and the clinical isolates of Gram-negative bacilli have increased significantly compared with Gram-positive cocci. In the clinical treatment of anti-infective diseases, antimicrobial agents should be selected according to the bacterial distribution characteristics and drug resistance in each hospital.
format	article
author	Huili Zhang Kairui Zhou Xinglong He Xin Yuan
author_facet	Huili Zhang Kairui Zhou Xinglong He Xin Yuan
author_sort	Huili Zhang
title	Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
title_short	Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
title_full	Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
title_fullStr	Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
title_full_unstemmed	Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
title_sort	comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0b6342fe4a044023af9bcf1b14bdf056
work_keys_str_mv	AT huilizhang comparativestudyonthechangesofbacterialspeciesandseverityofantimicrobialresistanceduring13years AT kairuizhou comparativestudyonthechangesofbacterialspeciesandseverityofantimicrobialresistanceduring13years AT xinglonghe comparativestudyonthechangesofbacterialspeciesandseverityofantimicrobialresistanceduring13years AT xinyuan comparativestudyonthechangesofbacterialspeciesandseverityofantimicrobialresistanceduring13years
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Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years.

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