Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine models of lung fibrosis via αvβ6 degradation....

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Autores principales:	Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
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spelling	oai:doaj.org-article:0b6e5916f4cb4d2e9b4186f07f1b86ee2021-12-02T18:02:16ZTranslational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis10.1038/s41467-020-18397-62041-1723https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18397-6https://doaj.org/toc/2041-1723The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine models of lung fibrosis via αvβ6 degradation.Alison E. JohnRebecca H. GravesK. Tao PunGiovanni VitulliEllen J. FortyPaul F. MercerJosie L. MorrellJohn W. BarrettRebecca F. RogersMaryam HafejiLloyd I. BibbyElaine GowerValerie S. MorrisonYim ManJames A. RoperJeni C. LuckettLee A. BorthwickBen S. BarksbyRachel A. BurgoyneRory BarnesJoelle LeDavid J. FlintSusan PyneAnthony HabgoodLouise A. OrganChitra JosephRochelle C. Edwards-PritchardToby M. MaherAndrew J. FisherNatasja Stæhr GudmannDiana J. LeemingRachel C. ChambersPauline T. LukeyRichard P. MarshallSimon J. F. MacdonaldR. Gisli JenkinsRobert J. SlackNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alison E. John Rebecca H. Graves K. Tao Pun Giovanni Vitulli Ellen J. Forty Paul F. Mercer Josie L. Morrell John W. Barrett Rebecca F. Rogers Maryam Hafeji Lloyd I. Bibby Elaine Gower Valerie S. Morrison Yim Man James A. Roper Jeni C. Luckett Lee A. Borthwick Ben S. Barksby Rachel A. Burgoyne Rory Barnes Joelle Le David J. Flint Susan Pyne Anthony Habgood Louise A. Organ Chitra Joseph Rochelle C. Edwards-Pritchard Toby M. Maher Andrew J. Fisher Natasja Stæhr Gudmann Diana J. Leeming Rachel C. Chambers Pauline T. Lukey Richard P. Marshall Simon J. F. Macdonald R. Gisli Jenkins Robert J. Slack Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
description	The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine models of lung fibrosis via αvβ6 degradation.
format	article
author	Alison E. John Rebecca H. Graves K. Tao Pun Giovanni Vitulli Ellen J. Forty Paul F. Mercer Josie L. Morrell John W. Barrett Rebecca F. Rogers Maryam Hafeji Lloyd I. Bibby Elaine Gower Valerie S. Morrison Yim Man James A. Roper Jeni C. Luckett Lee A. Borthwick Ben S. Barksby Rachel A. Burgoyne Rory Barnes Joelle Le David J. Flint Susan Pyne Anthony Habgood Louise A. Organ Chitra Joseph Rochelle C. Edwards-Pritchard Toby M. Maher Andrew J. Fisher Natasja Stæhr Gudmann Diana J. Leeming Rachel C. Chambers Pauline T. Lukey Richard P. Marshall Simon J. F. Macdonald R. Gisli Jenkins Robert J. Slack
author_facet	Alison E. John Rebecca H. Graves K. Tao Pun Giovanni Vitulli Ellen J. Forty Paul F. Mercer Josie L. Morrell John W. Barrett Rebecca F. Rogers Maryam Hafeji Lloyd I. Bibby Elaine Gower Valerie S. Morrison Yim Man James A. Roper Jeni C. Luckett Lee A. Borthwick Ben S. Barksby Rachel A. Burgoyne Rory Barnes Joelle Le David J. Flint Susan Pyne Anthony Habgood Louise A. Organ Chitra Joseph Rochelle C. Edwards-Pritchard Toby M. Maher Andrew J. Fisher Natasja Stæhr Gudmann Diana J. Leeming Rachel C. Chambers Pauline T. Lukey Richard P. Marshall Simon J. F. Macdonald R. Gisli Jenkins Robert J. Slack
author_sort	Alison E. John
title	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
title_short	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
title_full	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
title_fullStr	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
title_full_unstemmed	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
title_sort	translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

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