Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro

Xin-Xing Wang,1,2,* Ying-Ying Zha,3,* Bo Yang,1 Lin Chen,1,2 Ming Wang1,2 1CAS Key Laboratory of Brain Function and Diseases, 2Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 3Cell Electrophysi...

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Autores principales:	Wang XX, Zha YY, Yang B, Chen L, Wang M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	fullerenol hippocampal slice nitric oxide synthase synaptic plasticity oxidative stress Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0b70198278b5437dacd085d8800aed88
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spelling	oai:doaj.org-article:0b70198278b5437dacd085d8800aed882021-12-02T00:38:48ZSuppression of synaptic plasticity by fullerenol in rat hippocampus in vitro1178-2013https://doaj.org/article/0b70198278b5437dacd085d8800aed882016-09-01T00:00:00Zhttps://www.dovepress.com/suppression-of-synaptic-plasticity-by-fullerenol-in-rat-hippocampus-in-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xin-Xing Wang,1,2,* Ying-Ying Zha,3,* Bo Yang,1 Lin Chen,1,2 Ming Wang1,2 1CAS Key Laboratory of Brain Function and Diseases, 2Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 3Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, Anhui, People’s Republic of China *These authors contributed equally to this work Abstract: Fullerenol, a water-soluble fullerene derivative, has attracted much attention due to its bioactive properties, including the antioxidative properties and free radical scavenging ability. Due to its superior nature, fullerenol represents a promising diagnostic, therapeutic, and protective agent. Therefore, elucidation of the possible side effects of fullerenol is important in determining its potential role. In the present study, we investigated the acute effects of 5 µM fullerenol on synaptic plasticity in hippocampal brain slices of rats. Incubation with fullerenol for 20 minutes significantly decreased the peak of paired-pulse facilitation and long-term potentiation, indicating that fullerenol suppresses the short- and long-term synaptic plasticity of region I of hippocampus. We found that fullerenol depressed the activity and the expression of nitric oxide (NO) synthase in hippocampus. In view of the important role of NO in synaptic plasticity, the inhibition of fullerenol on NO synthase may contribute to the suppression of synaptic plasticity. These findings may facilitate the evaluation of the side effects of fullerenol. Keywords: fullerenol, hippocampal slice, nitric oxide synthase, synaptic plasticity, oxidative stressWang XXZha YYYang BChen LWang MDove Medical Pressarticlefullerenolhippocampal slicenitric oxide synthasesynaptic plasticityoxidative stressMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4947-4955 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	fullerenol hippocampal slice nitric oxide synthase synaptic plasticity oxidative stress Medicine (General) R5-920
spellingShingle	fullerenol hippocampal slice nitric oxide synthase synaptic plasticity oxidative stress Medicine (General) R5-920 Wang XX Zha YY Yang B Chen L Wang M Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
description	Xin-Xing Wang,1,2,* Ying-Ying Zha,3,* Bo Yang,1 Lin Chen,1,2 Ming Wang1,2 1CAS Key Laboratory of Brain Function and Diseases, 2Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 3Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, Anhui, People’s Republic of China *These authors contributed equally to this work Abstract: Fullerenol, a water-soluble fullerene derivative, has attracted much attention due to its bioactive properties, including the antioxidative properties and free radical scavenging ability. Due to its superior nature, fullerenol represents a promising diagnostic, therapeutic, and protective agent. Therefore, elucidation of the possible side effects of fullerenol is important in determining its potential role. In the present study, we investigated the acute effects of 5 µM fullerenol on synaptic plasticity in hippocampal brain slices of rats. Incubation with fullerenol for 20 minutes significantly decreased the peak of paired-pulse facilitation and long-term potentiation, indicating that fullerenol suppresses the short- and long-term synaptic plasticity of region I of hippocampus. We found that fullerenol depressed the activity and the expression of nitric oxide (NO) synthase in hippocampus. In view of the important role of NO in synaptic plasticity, the inhibition of fullerenol on NO synthase may contribute to the suppression of synaptic plasticity. These findings may facilitate the evaluation of the side effects of fullerenol. Keywords: fullerenol, hippocampal slice, nitric oxide synthase, synaptic plasticity, oxidative stress
format	article
author	Wang XX Zha YY Yang B Chen L Wang M
author_facet	Wang XX Zha YY Yang B Chen L Wang M
author_sort	Wang XX
title	Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
title_short	Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
title_full	Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
title_fullStr	Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
title_full_unstemmed	Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
title_sort	suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0b70198278b5437dacd085d8800aed88
work_keys_str_mv	AT wangxx suppressionofsynapticplasticitybyfullerenolinrathippocampusinvitro AT zhayy suppressionofsynapticplasticitybyfullerenolinrathippocampusinvitro AT yangb suppressionofsynapticplasticitybyfullerenolinrathippocampusinvitro AT chenl suppressionofsynapticplasticitybyfullerenolinrathippocampusinvitro AT wangm suppressionofsynapticplasticitybyfullerenolinrathippocampusinvitro
_version_	1718403537420943360

Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro

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