Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

The peptide hormone hepcidin is released from hepatocytes and regulates iron homoeostasis. Here, the authors show that hepcidin also regulates the activation of hepatic stellate cells (HSCs) in mouse models of liver fibrosis by reducing ferroportin expression and inhibiting the HSC response to TGFβ....

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Autores principales:	Chang Yeob Han, Ja Hyun Koo, Sung Hoon Kim, Sara Gardenghi, Stefano Rivella, Pavel Strnad, Se Jin Hwang, Sang Geon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b704ac11ee74eaa8b59c326f11fc5a4
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spelling	oai:doaj.org-article:0b704ac11ee74eaa8b59c326f11fc5a42021-12-02T15:34:53ZHepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt10.1038/ncomms138172041-1723https://doaj.org/article/0b704ac11ee74eaa8b59c326f11fc5a42016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13817https://doaj.org/toc/2041-1723The peptide hormone hepcidin is released from hepatocytes and regulates iron homoeostasis. Here, the authors show that hepcidin also regulates the activation of hepatic stellate cells (HSCs) in mouse models of liver fibrosis by reducing ferroportin expression and inhibiting the HSC response to TGFβ.Chang Yeob HanJa Hyun KooSung Hoon KimSara GardenghiStefano RivellaPavel StrnadSe Jin HwangSang Geon KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang Yeob Han Ja Hyun Koo Sung Hoon Kim Sara Gardenghi Stefano Rivella Pavel Strnad Se Jin Hwang Sang Geon Kim Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
description	The peptide hormone hepcidin is released from hepatocytes and regulates iron homoeostasis. Here, the authors show that hepcidin also regulates the activation of hepatic stellate cells (HSCs) in mouse models of liver fibrosis by reducing ferroportin expression and inhibiting the HSC response to TGFβ.
format	article
author	Chang Yeob Han Ja Hyun Koo Sung Hoon Kim Sara Gardenghi Stefano Rivella Pavel Strnad Se Jin Hwang Sang Geon Kim
author_facet	Chang Yeob Han Ja Hyun Koo Sung Hoon Kim Sara Gardenghi Stefano Rivella Pavel Strnad Se Jin Hwang Sang Geon Kim
author_sort	Chang Yeob Han
title	Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
title_short	Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
title_full	Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
title_fullStr	Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
title_full_unstemmed	Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
title_sort	hepcidin inhibits smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of akt
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0b704ac11ee74eaa8b59c326f11fc5a4
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Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

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