In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.

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Autores principales:	Sebastian Groß, Bastien Schnell, Patrick A. Haack, David Auerbach, Rolf Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b7437a9990648c78f101efed6acc7c3
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spelling	oai:doaj.org-article:0b7437a9990648c78f101efed6acc7c32021-12-02T13:17:39ZIn vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis10.1038/s41467-021-21848-32041-1723https://doaj.org/article/0b7437a9990648c78f101efed6acc7c32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21848-3https://doaj.org/toc/2041-1723The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.Sebastian GroßBastien SchnellPatrick A. HaackDavid AuerbachRolf MüllerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Groß Bastien Schnell Patrick A. Haack David Auerbach Rolf Müller In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
description	The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.
format	article
author	Sebastian Groß Bastien Schnell Patrick A. Haack David Auerbach Rolf Müller
author_facet	Sebastian Groß Bastien Schnell Patrick A. Haack David Auerbach Rolf Müller
author_sort	Sebastian Groß
title	In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_short	In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_full	In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_fullStr	In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_full_unstemmed	In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
title_sort	in vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0b7437a9990648c78f101efed6acc7c3
work_keys_str_mv	AT sebastiangroß invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis AT bastienschnell invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis AT patrickahaack invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis AT davidauerbach invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis AT rolfmuller invivoandinvitroreconstitutionofuniquekeystepsincystobactamidantibioticbiosynthesis
_version_	1718393314046115840

In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

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