In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear. Here, the authors report in vivo and in vitro evidence for unique steps in cystobactamid biosynthesis.

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Bibliographic Details
Main Authors: Sebastian Groß, Bastien Schnell, Patrick A. Haack, David Auerbach, Rolf Müller
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/0b7437a9990648c78f101efed6acc7c3
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