Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study

Abstract The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) and brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT...

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Autores principales:	Agostino Chiaravalloti, Francesco Ursini, Alessandro Fiorentini, Gaetano Barbagallo, Alessandro Martorana, Giacomo Koch, Mario Tavolozza, Orazio Schillaci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b744b0f73694a13b8f8ea3ba0ec3f0d
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spelling	oai:doaj.org-article:0b744b0f73694a13b8f8ea3ba0ec3f0d2021-12-02T16:08:13ZFunctional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study10.1038/s41598-017-06138-72045-2322https://doaj.org/article/0b744b0f73694a13b8f8ea3ba0ec3f0d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06138-7https://doaj.org/toc/2045-2322Abstract The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) and brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in a selected population with Alzheimer disease (AD). We evaluated 87 subjects (37 males and 50 females, mean age 70 (±6) years old) with AD. All of them were subjected to TSH, fT3 and fT4 assay and to cerebrospinal fluid amyloid (Aβ1-42) and tau [phosphorylated-tau (p-tau) and total-tau (t-tau)] assay prior PET/CT examination. Values for TSH, fT3 and fT4 were in the normal range. The relationships were evaluated by means of statistical parametric mapping (SPM8) using age, sex, MMSE, scholarship and CSF values of amyloid and tau as covariates. We found a significant positive correlation between TSH values and cortical glucose consumption in a wide portion of the anterior cingulate cortex bilaterally (BA32) and left frontal lobe (BA25) (p FWE-corr <0.001; p FDRcorr <0.000; cluster extent 66950). No significant relationships were found between cortical F-18 FDG uptake and T3 and T4 serum levels. The results of our study suggest that a cortical dysfunction in anterior cingulate and frontal lobes may affect serum values of TSH in AD patients.Agostino ChiaravallotiFrancesco UrsiniAlessandro FiorentiniGaetano BarbagalloAlessandro MartoranaGiacomo KochMario TavolozzaOrazio SchillaciNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agostino Chiaravalloti Francesco Ursini Alessandro Fiorentini Gaetano Barbagallo Alessandro Martorana Giacomo Koch Mario Tavolozza Orazio Schillaci Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
description	Abstract The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) and brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in a selected population with Alzheimer disease (AD). We evaluated 87 subjects (37 males and 50 females, mean age 70 (±6) years old) with AD. All of them were subjected to TSH, fT3 and fT4 assay and to cerebrospinal fluid amyloid (Aβ1-42) and tau [phosphorylated-tau (p-tau) and total-tau (t-tau)] assay prior PET/CT examination. Values for TSH, fT3 and fT4 were in the normal range. The relationships were evaluated by means of statistical parametric mapping (SPM8) using age, sex, MMSE, scholarship and CSF values of amyloid and tau as covariates. We found a significant positive correlation between TSH values and cortical glucose consumption in a wide portion of the anterior cingulate cortex bilaterally (BA32) and left frontal lobe (BA25) (p FWE-corr <0.001; p FDRcorr <0.000; cluster extent 66950). No significant relationships were found between cortical F-18 FDG uptake and T3 and T4 serum levels. The results of our study suggest that a cortical dysfunction in anterior cingulate and frontal lobes may affect serum values of TSH in AD patients.
format	article
author	Agostino Chiaravalloti Francesco Ursini Alessandro Fiorentini Gaetano Barbagallo Alessandro Martorana Giacomo Koch Mario Tavolozza Orazio Schillaci
author_facet	Agostino Chiaravalloti Francesco Ursini Alessandro Fiorentini Gaetano Barbagallo Alessandro Martorana Giacomo Koch Mario Tavolozza Orazio Schillaci
author_sort	Agostino Chiaravalloti
title	Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
title_short	Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
title_full	Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
title_fullStr	Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
title_full_unstemmed	Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
title_sort	functional correlates of tsh, ft3 and ft4 in alzheimer disease: a f-18 fdg pet/ct study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0b744b0f73694a13b8f8ea3ba0ec3f0d
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Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study

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