Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.

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Autores principales:	Christophe Chopard, Phuoc Bao Viet Tong, Petra Tóth, Malvina Schatz, Hocine Yezid, Solène Debaisieux, Clément Mettling, Antoine Gross, Martine Pugnière, Annie Tu, Jean-Marc Strub, Jean-Michel Mesnard, Nicolas Vitale, Bruno Beaumelle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b76da00f3d140a9bf12b239560dc94a
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spelling	oai:doaj.org-article:0b76da00f3d140a9bf12b239560dc94a2021-12-02T16:49:52ZCyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells10.1038/s41467-018-04674-y2041-1723https://doaj.org/article/0b76da00f3d140a9bf12b239560dc94a2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04674-yhttps://doaj.org/toc/2041-1723It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.Christophe ChopardPhuoc Bao Viet TongPetra TóthMalvina SchatzHocine YezidSolène DebaisieuxClément MettlingAntoine GrossMartine PugnièreAnnie TuJean-Marc StrubJean-Michel MesnardNicolas VitaleBruno BeaumelleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
description	It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.
format	article
author	Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle
author_facet	Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle
author_sort	Christophe Chopard
title	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_short	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_full	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_fullStr	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_full_unstemmed	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_sort	cyclophilin a enables specific hiv-1 tat palmitoylation and accumulation in uninfected cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0b76da00f3d140a9bf12b239560dc94a
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Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

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