Histone chaperone exploits intrinsic disorder to switch acetylation specificity
Histone chaperones have been shown to control the activity and specificity of histone-modifying enzymes. Here the authors establish a structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4, finding that Vps75 promotes K9-acetylation by engaging th...
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Autores principales: | Nataliya Danilenko, Lukas Lercher, John Kirkpatrick, Frank Gabel, Luca Codutti, Teresa Carlomagno |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Acceso en línea: | https://doaj.org/article/0b7982cadac74428b575ac9e21c9f021 |
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