Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the cytosol in a MAVS-dependent manner.

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Autores principales:	Miyu Moriyama, Takumi Koshiba, Takeshi Ichinohe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b79c42b444a4fddaa8705575ccaf3a8
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spelling	oai:doaj.org-article:0b79c42b444a4fddaa8705575ccaf3a82021-12-02T15:35:48ZInfluenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses10.1038/s41467-019-12632-52041-1723https://doaj.org/article/0b79c42b444a4fddaa8705575ccaf3a82019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12632-5https://doaj.org/toc/2041-1723Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the cytosol in a MAVS-dependent manner.Miyu MoriyamaTakumi KoshibaTakeshi IchinoheNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miyu Moriyama Takumi Koshiba Takeshi Ichinohe Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
description	Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the cytosol in a MAVS-dependent manner.
format	article
author	Miyu Moriyama Takumi Koshiba Takeshi Ichinohe
author_facet	Miyu Moriyama Takumi Koshiba Takeshi Ichinohe
author_sort	Miyu Moriyama
title	Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
title_short	Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
title_full	Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
title_fullStr	Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
title_full_unstemmed	Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
title_sort	influenza a virus m2 protein triggers mitochondrial dna-mediated antiviral immune responses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0b79c42b444a4fddaa8705575ccaf3a8
work_keys_str_mv	AT miyumoriyama influenzaavirusm2proteintriggersmitochondrialdnamediatedantiviralimmuneresponses AT takumikoshiba influenzaavirusm2proteintriggersmitochondrialdnamediatedantiviralimmuneresponses AT takeshiichinohe influenzaavirusm2proteintriggersmitochondrialdnamediatedantiviralimmuneresponses
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Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

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