A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease.
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory process of the lung inducing persistent airflow limitation. Extensive systemic effects, such as skeletal muscle dysfunction, often characterize these patients and severely limit life expectancy. Despite considerable research efforts, th...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0b7c520329024455986196c870dda6f7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0b7c520329024455986196c870dda6f7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0b7c520329024455986196c870dda6f72021-11-18T05:50:20ZA systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease.1553-734X1553-735810.1371/journal.pcbi.1002129https://doaj.org/article/0b7c520329024455986196c870dda6f72011-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21909251/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory process of the lung inducing persistent airflow limitation. Extensive systemic effects, such as skeletal muscle dysfunction, often characterize these patients and severely limit life expectancy. Despite considerable research efforts, the molecular basis of muscle degeneration in COPD is still a matter of intense debate. In this study, we have applied a network biology approach to model the relationship between muscle molecular and physiological response to training and systemic inflammatory mediators. Our model shows that failure to co-ordinately activate expression of several tissue remodelling and bioenergetics pathways is a specific landmark of COPD diseased muscles. Our findings also suggest that this phenomenon may be linked to an abnormal expression of a number of histone modifiers, which we discovered correlate with oxygen utilization. These observations raised the interesting possibility that cell hypoxia may be a key factor driving skeletal muscle degeneration in COPD patients.Nil TuranSusana KalkoAnna StinconeKim ClarkeAyesha SabahKatherine HowlettS John CurnowDiego A RodriguezMarta CascanteLaura O'NeillStuart EggintonJosep RocaFrancesco FalcianiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 9, p e1002129 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Nil Turan Susana Kalko Anna Stincone Kim Clarke Ayesha Sabah Katherine Howlett S John Curnow Diego A Rodriguez Marta Cascante Laura O'Neill Stuart Egginton Josep Roca Francesco Falciani A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| description |
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory process of the lung inducing persistent airflow limitation. Extensive systemic effects, such as skeletal muscle dysfunction, often characterize these patients and severely limit life expectancy. Despite considerable research efforts, the molecular basis of muscle degeneration in COPD is still a matter of intense debate. In this study, we have applied a network biology approach to model the relationship between muscle molecular and physiological response to training and systemic inflammatory mediators. Our model shows that failure to co-ordinately activate expression of several tissue remodelling and bioenergetics pathways is a specific landmark of COPD diseased muscles. Our findings also suggest that this phenomenon may be linked to an abnormal expression of a number of histone modifiers, which we discovered correlate with oxygen utilization. These observations raised the interesting possibility that cell hypoxia may be a key factor driving skeletal muscle degeneration in COPD patients. |
| format |
article |
| author |
Nil Turan Susana Kalko Anna Stincone Kim Clarke Ayesha Sabah Katherine Howlett S John Curnow Diego A Rodriguez Marta Cascante Laura O'Neill Stuart Egginton Josep Roca Francesco Falciani |
| author_facet |
Nil Turan Susana Kalko Anna Stincone Kim Clarke Ayesha Sabah Katherine Howlett S John Curnow Diego A Rodriguez Marta Cascante Laura O'Neill Stuart Egginton Josep Roca Francesco Falciani |
| author_sort |
Nil Turan |
| title |
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| title_short |
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| title_full |
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| title_fullStr |
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| title_full_unstemmed |
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| title_sort |
systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/0b7c520329024455986196c870dda6f7 |
| work_keys_str_mv |
AT nilturan asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT susanakalko asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT annastincone asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT kimclarke asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT ayeshasabah asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT katherinehowlett asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT sjohncurnow asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT diegoarodriguez asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT martacascante asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT lauraoneill asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT stuartegginton asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT joseproca asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT francescofalciani asystemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT nilturan systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT susanakalko systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT annastincone systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT kimclarke systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT ayeshasabah systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT katherinehowlett systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT sjohncurnow systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT diegoarodriguez systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT martacascante systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT lauraoneill systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT stuartegginton systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT joseproca systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease AT francescofalciani systemsbiologyapproachidentifiesmolecularnetworksdefiningskeletalmuscleabnormalitiesinchronicobstructivepulmonarydisease |
| _version_ |
1718424770205188096 |