Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Abstract The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani pris...

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Autores principales:	Muhammad Imran Qadeer, Ali Amar, Yung-Yu Huang, Eli Min, Hanga Galfalvy, Shahida Hasnain, J. John Mann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b7efe7db0a2463085455826f10fa6c2
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spelling	oai:doaj.org-article:0b7efe7db0a2463085455826f10fa6c22021-12-02T11:50:40ZAssociation of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin10.1038/s41598-021-81198-42045-2322https://doaj.org/article/0b7efe7db0a2463085455826f10fa6c22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81198-4https://doaj.org/toc/2045-2322Abstract The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and LA/LA variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and LA/LA genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/LG, LG/LG) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship.Muhammad Imran QadeerAli AmarYung-Yu HuangEli MinHanga GalfalvyShahida HasnainJ. John MannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad Imran Qadeer Ali Amar Yung-Yu Huang Eli Min Hanga Galfalvy Shahida Hasnain J. John Mann Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
description	Abstract The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and LA/LA variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and LA/LA genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/LG, LG/LG) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship.
format	article
author	Muhammad Imran Qadeer Ali Amar Yung-Yu Huang Eli Min Hanga Galfalvy Shahida Hasnain J. John Mann
author_facet	Muhammad Imran Qadeer Ali Amar Yung-Yu Huang Eli Min Hanga Galfalvy Shahida Hasnain J. John Mann
author_sort	Muhammad Imran Qadeer
title	Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_short	Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_full	Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_fullStr	Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_full_unstemmed	Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_sort	association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of pakistani origin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0b7efe7db0a2463085455826f10fa6c2
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Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

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