Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation

Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation

Xenotransplantation is a potential solution for the severe shortage of human donor organs and tissues. The generation of humanized animal models attenuates strong innate immune responses, such as complement-mediated hyperacute rejection. However, acute vascular rejection and cell mediated rejection...

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Autores principales: Yunhan Ma, Baiyi Xie, Junjun Guo, Yingyu Chen, Mengya Zhong, Qingru Lin, Jianyu Hua, Jiaying Zhong, Xuewei Luo, Guoliang Yan, Helong Dai, Zhongquan Qi
Formato: article
Lenguaje:EN
Publicado: SAGE Publishing 2021
Materias:
Medicine
R
Acceso en línea:https://doaj.org/article/0b8064bd5a1c498f85293c37590d46d2
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