Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures associated with the number and character of signat...

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Autores principales:	Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen, Gaëtan MacGrogan, Gert G. G. M. Van den Eynden, Colin Purdie, Alastair M. Thompson, Carlos Caldas, Paul N. Span, Peter T. Simpson, Sunil R. Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P. Andrew Futreal, Stian Knappskog, Tari King, Gilles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G. Stunnenberg, Mike Stratton, John A. Foekens, John W. M. Martens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b
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spelling	oai:doaj.org-article:0b80834b0f74411a8fac98a9ae2db59b2021-12-02T15:34:55ZBreast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration10.1038/ncomms129102041-1723https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12910https://doaj.org/toc/2041-1723Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures associated with the number and character of signature mutations.Marcel SmidF. Germán Rodríguez-GonzálezAnieta M. SieuwertsRoberto SalgadoWendy J. C. Prager-Van der SmissenMichelle van der Vlugt-DaaneAnne van GalenSerena Nik-ZainalJohan StaafArie B. BrinkmanMarc J. van de VijverAndrea L. RichardsonAquila FatimaKim BerentsenAdam ButlerSancha MartinHelen R. DaviesReno DebetsMarion E. Meijer-Van GelderCarolien H. M. van DeurzenGaëtan MacGroganGert G. G. M. Van den EyndenColin PurdieAlastair M. ThompsonCarlos CaldasPaul N. SpanPeter T. SimpsonSunil R. LakhaniSteven Van LaereChristine DesmedtMarkus RingnérStefania TommasiJorunn EyfordAnnegien BroeksAnne Vincent-SalomonP. Andrew FutrealStian KnappskogTari KingGilles ThomasAlain ViariAnita LangerødAnne-Lise Børresen-DaleEwan BirneyHendrik G. StunnenbergMike StrattonJohn A. FoekensJohn W. M. MartensNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marcel Smid F. Germán Rodríguez-González Anieta M. Sieuwerts Roberto Salgado Wendy J. C. Prager-Van der Smissen Michelle van der Vlugt-Daane Anne van Galen Serena Nik-Zainal Johan Staaf Arie B. Brinkman Marc J. van de Vijver Andrea L. Richardson Aquila Fatima Kim Berentsen Adam Butler Sancha Martin Helen R. Davies Reno Debets Marion E. Meijer-Van Gelder Carolien H. M. van Deurzen Gaëtan MacGrogan Gert G. G. M. Van den Eynden Colin Purdie Alastair M. Thompson Carlos Caldas Paul N. Span Peter T. Simpson Sunil R. Lakhani Steven Van Laere Christine Desmedt Markus Ringnér Stefania Tommasi Jorunn Eyford Annegien Broeks Anne Vincent-Salomon P. Andrew Futreal Stian Knappskog Tari King Gilles Thomas Alain Viari Anita Langerød Anne-Lise Børresen-Dale Ewan Birney Hendrik G. Stunnenberg Mike Stratton John A. Foekens John W. M. Martens Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
description	Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures associated with the number and character of signature mutations.
format	article
author	Marcel Smid F. Germán Rodríguez-González Anieta M. Sieuwerts Roberto Salgado Wendy J. C. Prager-Van der Smissen Michelle van der Vlugt-Daane Anne van Galen Serena Nik-Zainal Johan Staaf Arie B. Brinkman Marc J. van de Vijver Andrea L. Richardson Aquila Fatima Kim Berentsen Adam Butler Sancha Martin Helen R. Davies Reno Debets Marion E. Meijer-Van Gelder Carolien H. M. van Deurzen Gaëtan MacGrogan Gert G. G. M. Van den Eynden Colin Purdie Alastair M. Thompson Carlos Caldas Paul N. Span Peter T. Simpson Sunil R. Lakhani Steven Van Laere Christine Desmedt Markus Ringnér Stefania Tommasi Jorunn Eyford Annegien Broeks Anne Vincent-Salomon P. Andrew Futreal Stian Knappskog Tari King Gilles Thomas Alain Viari Anita Langerød Anne-Lise Børresen-Dale Ewan Birney Hendrik G. Stunnenberg Mike Stratton John A. Foekens John W. M. Martens
author_facet	Marcel Smid F. Germán Rodríguez-González Anieta M. Sieuwerts Roberto Salgado Wendy J. C. Prager-Van der Smissen Michelle van der Vlugt-Daane Anne van Galen Serena Nik-Zainal Johan Staaf Arie B. Brinkman Marc J. van de Vijver Andrea L. Richardson Aquila Fatima Kim Berentsen Adam Butler Sancha Martin Helen R. Davies Reno Debets Marion E. Meijer-Van Gelder Carolien H. M. van Deurzen Gaëtan MacGrogan Gert G. G. M. Van den Eynden Colin Purdie Alastair M. Thompson Carlos Caldas Paul N. Span Peter T. Simpson Sunil R. Lakhani Steven Van Laere Christine Desmedt Markus Ringnér Stefania Tommasi Jorunn Eyford Annegien Broeks Anne Vincent-Salomon P. Andrew Futreal Stian Knappskog Tari King Gilles Thomas Alain Viari Anita Langerød Anne-Lise Børresen-Dale Ewan Birney Hendrik G. Stunnenberg Mike Stratton John A. Foekens John W. M. Martens
author_sort	Marcel Smid
title	Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
title_short	Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
title_full	Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
title_fullStr	Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
title_full_unstemmed	Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
title_sort	breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b
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Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

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