Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient

Chang-Min Chung,1,2 Hui-Wen Cheng,2 Jung-Jung Chang,2 Yu-Sheng Lin,2 Ju-Feng Hsiao,2 Shih-Tai Chang,1 Jen-Te Hsu2,31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 2Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 3Department of Medi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chung CM, Cheng HW, Chang JJ, Lin YS, Hsiao JF, Chang ST, Hsu JT
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://doaj.org/article/0b80f938cb144f19b0c415651dd5079d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0b80f938cb144f19b0c415651dd5079d
record_format dspace
spelling oai:doaj.org-article:0b80f938cb144f19b0c415651dd5079d2021-12-02T03:10:05ZRelationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient1178-1998https://doaj.org/article/0b80f938cb144f19b0c415651dd5079d2014-09-01T00:00:00Zhttps://www.dovepress.com/relationship-between-resistant-hypertension-andnbsparterial-stiffness--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chang-Min Chung,1,2 Hui-Wen Cheng,2 Jung-Jung Chang,2 Yu-Sheng Lin,2 Ju-Feng Hsiao,2 Shih-Tai Chang,1 Jen-Te Hsu2,31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 2Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 3Department of Medicine, College of Medicine, Chang Gung University, Taoyuan County, TaiwanBackground: Resistant hypertension (RH) is a common clinical condition associated with increased cardiovascular mortality and morbidity in older patients. Several factors and conditions interfering with blood pressure (BP) control, such as excess sodium intake, obesity, diabetes, older age, kidney disease, and certain identifiable causes of hypertension are common in patients resistant to antihypertensive treatment. Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is increasingly recognized as an important prognostic index and potential therapeutic target in hypertensive patients. The aim of this study was to determine whether there is an association between RH and arterial stiffness. Methods: This study included 1,620 patients aged ≥65 years who were referred or self-referred to the outpatient hypertension unit located at a single cardiovascular center. They were separated into normotensive, controlled BP, and resistant hypertension groups. Home BP, blood laboratory parameters, echocardiographic studies and baPWV all were measured. Results: The likelihood of diabetes mellitus was significantly greater in the RH group than in the group with controlled BP (odds ratio 2.114, 95% confidence interval [CI] 1.194–3.744, P=0.010). Systolic BP was correlated in the RH group significantly more than in the group with controlled BP (odds ratio 1.032, 95% CI 1.012–1.053, P=0.001). baPWV (odds ratio 1.084, 95% CI 1.016–1.156, P=0.015) was significantly correlated with the presence of RH. The other factors were negatively correlated with the existence of RH.Conclusion: In patients aged ≥65 years, the patients with RH have elevated vascular stiffness more than the well controlled hypertension group. baPWV increased with arterial stiffness and was correlated with BP levels. Strict BP control is necessary to prevent severe functional and structural vascular changes in the course of hypertensive disease.Keywords: arterial stiffness, brachial-ankle pulse wave velocity, resistant hypertensionChung CMCheng HWChang JJLin YSHsiao JFChang STHsu JTDove Medical PressarticleArterial stiffnessbrachial-ankle pulse wave velocityresistant hypertensionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1495-1502 (2014)
institution DOAJ
collection DOAJ
language EN
topic Arterial stiffness
brachial-ankle pulse wave velocity
resistant hypertension
Geriatrics
RC952-954.6
spellingShingle Arterial stiffness
brachial-ankle pulse wave velocity
resistant hypertension
Geriatrics
RC952-954.6
Chung CM
Cheng HW
Chang JJ
Lin YS
Hsiao JF
Chang ST
Hsu JT
Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
description Chang-Min Chung,1,2 Hui-Wen Cheng,2 Jung-Jung Chang,2 Yu-Sheng Lin,2 Ju-Feng Hsiao,2 Shih-Tai Chang,1 Jen-Te Hsu2,31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 2Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 3Department of Medicine, College of Medicine, Chang Gung University, Taoyuan County, TaiwanBackground: Resistant hypertension (RH) is a common clinical condition associated with increased cardiovascular mortality and morbidity in older patients. Several factors and conditions interfering with blood pressure (BP) control, such as excess sodium intake, obesity, diabetes, older age, kidney disease, and certain identifiable causes of hypertension are common in patients resistant to antihypertensive treatment. Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is increasingly recognized as an important prognostic index and potential therapeutic target in hypertensive patients. The aim of this study was to determine whether there is an association between RH and arterial stiffness. Methods: This study included 1,620 patients aged ≥65 years who were referred or self-referred to the outpatient hypertension unit located at a single cardiovascular center. They were separated into normotensive, controlled BP, and resistant hypertension groups. Home BP, blood laboratory parameters, echocardiographic studies and baPWV all were measured. Results: The likelihood of diabetes mellitus was significantly greater in the RH group than in the group with controlled BP (odds ratio 2.114, 95% confidence interval [CI] 1.194–3.744, P=0.010). Systolic BP was correlated in the RH group significantly more than in the group with controlled BP (odds ratio 1.032, 95% CI 1.012–1.053, P=0.001). baPWV (odds ratio 1.084, 95% CI 1.016–1.156, P=0.015) was significantly correlated with the presence of RH. The other factors were negatively correlated with the existence of RH.Conclusion: In patients aged ≥65 years, the patients with RH have elevated vascular stiffness more than the well controlled hypertension group. baPWV increased with arterial stiffness and was correlated with BP levels. Strict BP control is necessary to prevent severe functional and structural vascular changes in the course of hypertensive disease.Keywords: arterial stiffness, brachial-ankle pulse wave velocity, resistant hypertension
format article
author Chung CM
Cheng HW
Chang JJ
Lin YS
Hsiao JF
Chang ST
Hsu JT
author_facet Chung CM
Cheng HW
Chang JJ
Lin YS
Hsiao JF
Chang ST
Hsu JT
author_sort Chung CM
title Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
title_short Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
title_full Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
title_fullStr Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
title_full_unstemmed Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
title_sort relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/0b80f938cb144f19b0c415651dd5079d
work_keys_str_mv AT chungcm relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT chenghw relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT changjj relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT linys relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT hsiaojf relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT changst relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
AT hsujt relationshipbetweenresistanthypertensionandnbsparterialstiffnessassessednbspbybrachialanklepulsewavevelocityintheolderpatient
_version_ 1718401900404015104