Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology

The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of ca...

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Autores principales:	Edoardo Bertero, Pietro Ameri, Christoph Maack
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/0b819998f65a4295a9b2b3e0d47764d9
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spelling	oai:doaj.org-article:0b819998f65a4295a9b2b3e0d47764d92021-12-04T16:01:37ZBidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology10.15420/cfr.2019.1.22057-75592057-7540https://doaj.org/article/0b819998f65a4295a9b2b3e0d47764d92019-05-01T00:00:00Zhttps://www.cfrjournal.com/articles/Bidirectional-Relationship-Cancer-Heart-Failure-Cardio-Oncologyhttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF. On this basis, it has been proposed that HF might represent an oncogenic condition. This hypothesis is supported by preclinical studies demonstrating that hyperactivation of the sympathetic nervous system and renin–angiotensin–aldosterone system, which is a hallmark of HF, promotes cancer growth and dissemination. Another intriguing possibility is that the co-occurrence of HF and cancer is promoted by a common pathological milieu characterised by a state of chronic low-grade inflammation, which predisposes to both diseases. In this review, we provide an overview of the mechanisms underlying the bidirectional relationship between HF and cancer.Edoardo BerteroPietro AmeriChristoph MaackRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 5, Iss 2, Pp 106-111 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Edoardo Bertero Pietro Ameri Christoph Maack Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
description	The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF. On this basis, it has been proposed that HF might represent an oncogenic condition. This hypothesis is supported by preclinical studies demonstrating that hyperactivation of the sympathetic nervous system and renin–angiotensin–aldosterone system, which is a hallmark of HF, promotes cancer growth and dissemination. Another intriguing possibility is that the co-occurrence of HF and cancer is promoted by a common pathological milieu characterised by a state of chronic low-grade inflammation, which predisposes to both diseases. In this review, we provide an overview of the mechanisms underlying the bidirectional relationship between HF and cancer.
format	article
author	Edoardo Bertero Pietro Ameri Christoph Maack
author_facet	Edoardo Bertero Pietro Ameri Christoph Maack
author_sort	Edoardo Bertero
title	Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
title_short	Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
title_full	Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
title_fullStr	Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
title_full_unstemmed	Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
title_sort	bidirectional relationship between cancer and heart failure: old and new issues in cardio-oncology
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/0b819998f65a4295a9b2b3e0d47764d9
work_keys_str_mv	AT edoardobertero bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology AT pietroameri bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology AT christophmaack bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology
_version_	1718372717537787904

Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology

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