Impaired inhibitory control in recreational cocaine users.

Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult r...

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Autores principales:	Lorenza S Colzato, Wery P M van den Wildenberg, Bernhard Hommel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b84149c864844119e3404113ec28822
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spelling	oai:doaj.org-article:0b84149c864844119e3404113ec288222021-11-25T06:10:30ZImpaired inhibitory control in recreational cocaine users.1932-620310.1371/journal.pone.0001143https://doaj.org/article/0b84149c864844119e3404113ec288222007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001143https://doaj.org/toc/1932-6203Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult recreational users and in a cocaine-free-matched sample controlled for age, race, gender distribution, level of intelligence, and alcohol consumption. Response inhibition and response execution were measured by a stop-signal paradigm. Results show that users and non users are comparable in terms of response execution but users need significantly more time to inhibit responses to stop-signals than non users. Interestingly, the magnitude of the inhibitory deficit was positively correlated with the individuals lifetime cocaine exposure suggesting that the magnitude of the impairment is proportional to the degree of cocaine consumed.Lorenza S ColzatoWery P M van den WildenbergBernhard HommelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 11, p e1143 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lorenza S Colzato Wery P M van den Wildenberg Bernhard Hommel Impaired inhibitory control in recreational cocaine users.
description	Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult recreational users and in a cocaine-free-matched sample controlled for age, race, gender distribution, level of intelligence, and alcohol consumption. Response inhibition and response execution were measured by a stop-signal paradigm. Results show that users and non users are comparable in terms of response execution but users need significantly more time to inhibit responses to stop-signals than non users. Interestingly, the magnitude of the inhibitory deficit was positively correlated with the individuals lifetime cocaine exposure suggesting that the magnitude of the impairment is proportional to the degree of cocaine consumed.
format	article
author	Lorenza S Colzato Wery P M van den Wildenberg Bernhard Hommel
author_facet	Lorenza S Colzato Wery P M van den Wildenberg Bernhard Hommel
author_sort	Lorenza S Colzato
title	Impaired inhibitory control in recreational cocaine users.
title_short	Impaired inhibitory control in recreational cocaine users.
title_full	Impaired inhibitory control in recreational cocaine users.
title_fullStr	Impaired inhibitory control in recreational cocaine users.
title_full_unstemmed	Impaired inhibitory control in recreational cocaine users.
title_sort	impaired inhibitory control in recreational cocaine users.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/0b84149c864844119e3404113ec28822
work_keys_str_mv	AT lorenzascolzato impairedinhibitorycontrolinrecreationalcocaineusers AT werypmvandenwildenberg impairedinhibitorycontrolinrecreationalcocaineusers AT bernhardhommel impairedinhibitorycontrolinrecreationalcocaineusers
_version_	1718414084840357888

Impaired inhibitory control in recreational cocaine users.

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