Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study

Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota an...

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Autores principales:	Raphaël Enaud, Sophie Cambos, Esther Viaud, Erwan Guichoux, Emilie Chancerel, Aline Marighetto, Nicole Etchamendy, Samantha Clark, Kamel Mohammedi, Daniela Cota, Laurence Delhaes, Blandine Gatta-Cherifi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cognition memory metagenomics microbiome microbiota mycobiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0b8782e057cb485289dbbcb007cc5b9e
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spelling	oai:doaj.org-article:0b8782e057cb485289dbbcb007cc5b9e2021-11-25T18:36:28ZGut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study10.3390/nu131140612072-6643https://doaj.org/article/0b8782e057cb485289dbbcb007cc5b9e2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4061https://doaj.org/toc/2072-6643Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9, <i>p</i> = 0.02, and SS scores: 9.7 ± 23.0 vs. 11.6 ± 2.9, <i>p</i> = 0.05). An increase in bacterial alpha-diversity, and <i>Ruminococcaceae</i>, <i>Prevotella, Agaricus</i>, <i>Rhodotorula</i>, <i>Dipodascus</i>, <i>Malassezia</i>, and <i>Mucor</i> were significantly associated with AVLT score improvement after BS, while an increase in <i>Prevotella</i> and a decrease in <i>Clostridium</i>, <i>Akkermansia,</i> <i>Dipodascus</i> and <i>Candida</i> were linked to SS scores improvement. We identified several changes in the microbial communities that differ according to the improvement of either the verbal or working memories, suggesting a complex gut-brain-axis that evolves after BS.Raphaël EnaudSophie CambosEsther ViaudErwan GuichouxEmilie ChancerelAline MarighettoNicole EtchamendySamantha ClarkKamel MohammediDaniela CotaLaurence DelhaesBlandine Gatta-CherifiMDPI AGarticlecognitionmemorymetagenomicsmicrobiomemicrobiotamycobiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4061, p 4061 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognition memory metagenomics microbiome microbiota mycobiota Nutrition. Foods and food supply TX341-641
spellingShingle	cognition memory metagenomics microbiome microbiota mycobiota Nutrition. Foods and food supply TX341-641 Raphaël Enaud Sophie Cambos Esther Viaud Erwan Guichoux Emilie Chancerel Aline Marighetto Nicole Etchamendy Samantha Clark Kamel Mohammedi Daniela Cota Laurence Delhaes Blandine Gatta-Cherifi Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
description	Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9, <i>p</i> = 0.02, and SS scores: 9.7 ± 23.0 vs. 11.6 ± 2.9, <i>p</i> = 0.05). An increase in bacterial alpha-diversity, and <i>Ruminococcaceae</i>, <i>Prevotella, Agaricus</i>, <i>Rhodotorula</i>, <i>Dipodascus</i>, <i>Malassezia</i>, and <i>Mucor</i> were significantly associated with AVLT score improvement after BS, while an increase in <i>Prevotella</i> and a decrease in <i>Clostridium</i>, <i>Akkermansia,</i> <i>Dipodascus</i> and <i>Candida</i> were linked to SS scores improvement. We identified several changes in the microbial communities that differ according to the improvement of either the verbal or working memories, suggesting a complex gut-brain-axis that evolves after BS.
format	article
author	Raphaël Enaud Sophie Cambos Esther Viaud Erwan Guichoux Emilie Chancerel Aline Marighetto Nicole Etchamendy Samantha Clark Kamel Mohammedi Daniela Cota Laurence Delhaes Blandine Gatta-Cherifi
author_facet	Raphaël Enaud Sophie Cambos Esther Viaud Erwan Guichoux Emilie Chancerel Aline Marighetto Nicole Etchamendy Samantha Clark Kamel Mohammedi Daniela Cota Laurence Delhaes Blandine Gatta-Cherifi
author_sort	Raphaël Enaud
title	Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
title_short	Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
title_full	Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
title_fullStr	Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
title_full_unstemmed	Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
title_sort	gut microbiota and mycobiota evolution is linked to memory improvement after bariatric surgery in obese patients: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0b8782e057cb485289dbbcb007cc5b9e
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Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study

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