Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study

Abstract We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 p...

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Autores principales:	Sophiya Garasia, Zainab Samaan, Hertzel C. Gerstein, James C. Engert, Viswanathan Mohan, Rafael Diaz, Sonia S. Anand, David Meyre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b88c32b8c38495989c02bcb4ba4d3fb
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spelling	oai:doaj.org-article:0b88c32b8c38495989c02bcb4ba4d3fb2021-12-02T12:30:51ZInfluence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study10.1038/s41598-017-01406-y2045-2322https://doaj.org/article/0b88c32b8c38495989c02bcb4ba4d3fb2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01406-yhttps://doaj.org/toc/2045-2322Abstract We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysglycemia. All participants had genotypic and phenotypic data collected at baseline and 9,930 participants were followed-up for a median of 3.3 years. Normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and T2D statuses were determined using an oral glucose tolerance test and the 2003 American Diabetes Association criteria. Depression was diagnosed at baseline using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV). Multivariate logistic regression models were adjusted for age, sex, ethnicity and body-mass index and an interaction term GS X depression was added to the model. After appropriate Bonferroni correction, no significant association between depression and T2D-related traits (IFG/IGT, T2D and dysglycemia), and no significant interaction between the GS and depression status was observed at baseline or follow-up. Our longitudinal data do not support an association between depression and abnormal glycemic status. Moreover, depression does not modify the effect of T2D predisposing gene variants.Sophiya GarasiaZainab SamaanHertzel C. GersteinJames C. EngertViswanathan MohanRafael DiazSonia S. AnandDavid MeyreNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophiya Garasia Zainab Samaan Hertzel C. Gerstein James C. Engert Viswanathan Mohan Rafael Diaz Sonia S. Anand David Meyre Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
description	Abstract We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysglycemia. All participants had genotypic and phenotypic data collected at baseline and 9,930 participants were followed-up for a median of 3.3 years. Normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and T2D statuses were determined using an oral glucose tolerance test and the 2003 American Diabetes Association criteria. Depression was diagnosed at baseline using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV). Multivariate logistic regression models were adjusted for age, sex, ethnicity and body-mass index and an interaction term GS X depression was added to the model. After appropriate Bonferroni correction, no significant association between depression and T2D-related traits (IFG/IGT, T2D and dysglycemia), and no significant interaction between the GS and depression status was observed at baseline or follow-up. Our longitudinal data do not support an association between depression and abnormal glycemic status. Moreover, depression does not modify the effect of T2D predisposing gene variants.
format	article
author	Sophiya Garasia Zainab Samaan Hertzel C. Gerstein James C. Engert Viswanathan Mohan Rafael Diaz Sonia S. Anand David Meyre
author_facet	Sophiya Garasia Zainab Samaan Hertzel C. Gerstein James C. Engert Viswanathan Mohan Rafael Diaz Sonia S. Anand David Meyre
author_sort	Sophiya Garasia
title	Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
title_short	Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
title_full	Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
title_fullStr	Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
title_full_unstemmed	Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
title_sort	influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0b88c32b8c38495989c02bcb4ba4d3fb
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Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study

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