Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia

Abstract Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome presenting with sustained hypophosphatemia. Treatment of choice is removal of the tumor causing the TIO, but identification of the culprit tumor by routine imaging is challenging. This study aimed to assess the usefulne...

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Autores principales:	Dong Yun Lee, Seung Hun Lee, Beom-Jun Kim, Wanlim Kim, Pil Whan Yoon, Sang Ju Lee, Seung Jun Oh, Jung-Min Koh, Jin-Sook Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b8a3f0513ce451ba1808f65dc3ec6a5
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spelling	oai:doaj.org-article:0b8a3f0513ce451ba1808f65dc3ec6a52021-12-02T13:50:42ZUsefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia10.1038/s41598-021-81491-22045-2322https://doaj.org/article/0b8a3f0513ce451ba1808f65dc3ec6a52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81491-2https://doaj.org/toc/2045-2322Abstract Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome presenting with sustained hypophosphatemia. Treatment of choice is removal of the tumor causing the TIO, but identification of the culprit tumor by routine imaging is challenging. This study aimed to assess the usefulness of somatostatin receptor imaging, called 68Ga-DOTATOC PET/CT, in the management of patients with TIO. Twelve patients who were suspected of having TIO underwent 68Ga-DOTATOC PET/CT. Lesion detectability and maximum standardized uptake value (SUVmax) were determined and retrospectively compared with the clinical/imaging surveillance and histopathologic diagnosis. The median duration of suspected TIO with hypophosphatemia was 7.8 years (range 2.1–21.0). Conventional radiologic and/or nuclear medicine images failed to identify the culprit tumors. However, 68Ga-DOTATOC PET/CT scans showed that 8 of the 12 patients had positive lesions, suggesting the presence of focal culprit tumors. The SUVmax of positive tumors was 1.9–45.7 (median: 11.5). Six skeletal lesions and two extra-skeletal lesions were identified. Seven of the lesions were pathologically confirmed as potential culprits of TIO. Hypophosphatemia was resolved in five patients who underwent lesion excision. The 68Ga-DOTATOC PET/CT is a useful whole-body imaging modality for the detection of causative tumors in patients with suspected TIO.Dong Yun LeeSeung Hun LeeBeom-Jun KimWanlim KimPil Whan YoonSang Ju LeeSeung Jun OhJung-Min KohJin-Sook RyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Yun Lee Seung Hun Lee Beom-Jun Kim Wanlim Kim Pil Whan Yoon Sang Ju Lee Seung Jun Oh Jung-Min Koh Jin-Sook Ryu Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
description	Abstract Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome presenting with sustained hypophosphatemia. Treatment of choice is removal of the tumor causing the TIO, but identification of the culprit tumor by routine imaging is challenging. This study aimed to assess the usefulness of somatostatin receptor imaging, called 68Ga-DOTATOC PET/CT, in the management of patients with TIO. Twelve patients who were suspected of having TIO underwent 68Ga-DOTATOC PET/CT. Lesion detectability and maximum standardized uptake value (SUVmax) were determined and retrospectively compared with the clinical/imaging surveillance and histopathologic diagnosis. The median duration of suspected TIO with hypophosphatemia was 7.8 years (range 2.1–21.0). Conventional radiologic and/or nuclear medicine images failed to identify the culprit tumors. However, 68Ga-DOTATOC PET/CT scans showed that 8 of the 12 patients had positive lesions, suggesting the presence of focal culprit tumors. The SUVmax of positive tumors was 1.9–45.7 (median: 11.5). Six skeletal lesions and two extra-skeletal lesions were identified. Seven of the lesions were pathologically confirmed as potential culprits of TIO. Hypophosphatemia was resolved in five patients who underwent lesion excision. The 68Ga-DOTATOC PET/CT is a useful whole-body imaging modality for the detection of causative tumors in patients with suspected TIO.
format	article
author	Dong Yun Lee Seung Hun Lee Beom-Jun Kim Wanlim Kim Pil Whan Yoon Sang Ju Lee Seung Jun Oh Jung-Min Koh Jin-Sook Ryu
author_facet	Dong Yun Lee Seung Hun Lee Beom-Jun Kim Wanlim Kim Pil Whan Yoon Sang Ju Lee Seung Jun Oh Jung-Min Koh Jin-Sook Ryu
author_sort	Dong Yun Lee
title	Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
title_short	Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
title_full	Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
title_fullStr	Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
title_full_unstemmed	Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia
title_sort	usefulness of 68ga-dotatoc pet/ct to localize the culprit tumor inducing osteomalacia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0b8a3f0513ce451ba1808f65dc3ec6a5
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Usefulness of 68Ga-DOTATOC PET/CT to localize the culprit tumor inducing osteomalacia

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