Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

Lack of HLA-matched hematopoietic stem cells (HSC) limits the number of patients with life-threatening blood disorders that can be treated by HSC transplantation. So far, insufficient understanding of the regulatory mechanisms governing human HSC has precluded the development of effective protocols...

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Autores principales: Mattias Magnusson, Maria I Sierra, Rajkumar Sasidharan, Sacha L Prashad, Melissa Romero, Pamela Saarikoski, Ben Van Handel, Andy Huang, Xinmin Li, Hanna K A Mikkola
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/0b8c4615dcdf4df7995130c53d242d9c
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