Finger somatotopy is preserved after tetraplegia but deteriorates over time

Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent affere...

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Autores principales:	Sanne Kikkert, Dario Pfyffer, Michaela Verling, Patrick Freund, Nicole Wenderoth
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	plasticity spinal cord injury somatotopy functional MRI hand tetraplegia Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0b8c9162a39d41e59d1dd644bf72b481
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spelling	oai:doaj.org-article:0b8c9162a39d41e59d1dd644bf72b4812021-11-08T16:13:57ZFinger somatotopy is preserved after tetraplegia but deteriorates over time10.7554/eLife.677132050-084Xe67713https://doaj.org/article/0b8c9162a39d41e59d1dd644bf72b4812021-10-01T00:00:00Zhttps://elifesciences.org/articles/67713https://doaj.org/toc/2050-084XPrevious studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI.Sanne KikkertDario PfyfferMichaela VerlingPatrick FreundNicole WenderotheLife Sciences Publications Ltdarticleplasticityspinal cord injurysomatotopyfunctional MRIhandtetraplegiaMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasticity spinal cord injury somatotopy functional MRI hand tetraplegia Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	plasticity spinal cord injury somatotopy functional MRI hand tetraplegia Medicine R Science Q Biology (General) QH301-705.5 Sanne Kikkert Dario Pfyffer Michaela Verling Patrick Freund Nicole Wenderoth Finger somatotopy is preserved after tetraplegia but deteriorates over time
description	Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI.
format	article
author	Sanne Kikkert Dario Pfyffer Michaela Verling Patrick Freund Nicole Wenderoth
author_facet	Sanne Kikkert Dario Pfyffer Michaela Verling Patrick Freund Nicole Wenderoth
author_sort	Sanne Kikkert
title	Finger somatotopy is preserved after tetraplegia but deteriorates over time
title_short	Finger somatotopy is preserved after tetraplegia but deteriorates over time
title_full	Finger somatotopy is preserved after tetraplegia but deteriorates over time
title_fullStr	Finger somatotopy is preserved after tetraplegia but deteriorates over time
title_full_unstemmed	Finger somatotopy is preserved after tetraplegia but deteriorates over time
title_sort	finger somatotopy is preserved after tetraplegia but deteriorates over time
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/0b8c9162a39d41e59d1dd644bf72b481
work_keys_str_mv	AT sannekikkert fingersomatotopyispreservedaftertetraplegiabutdeterioratesovertime AT dariopfyffer fingersomatotopyispreservedaftertetraplegiabutdeterioratesovertime AT michaelaverling fingersomatotopyispreservedaftertetraplegiabutdeterioratesovertime AT patrickfreund fingersomatotopyispreservedaftertetraplegiabutdeterioratesovertime AT nicolewenderoth fingersomatotopyispreservedaftertetraplegiabutdeterioratesovertime
_version_	1718441542726713344

Finger somatotopy is preserved after tetraplegia but deteriorates over time

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