Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7

Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7

Abstract The 2525 amino acid SMRT corepressor is an intrinsically disordered hub protein responsible for binding and coordinating the activities of multiple transcription factors and chromatin modifying enzymes. Here we have studied its interaction with HDAC7, a class IIa deacetylase that interacts...

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Autores principales: Danielle C. Desravines, Itziar Serna Martin, Robert Schneider, Philippe J. Mas, Nataliia Aleksandrova, Malene Ringkjøbing Jensen, Martin Blackledge, Darren J. Hart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0b8d250e25a8437cb57a64f0045febb5
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