First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient

ABSTRACT An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistan...

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Autores principales:	Kalyan D. Chavda, Lars F. Westblade, Michael J. Satlin, Andrew C. Hemmert, Mariana Castanheira, Stephen G. Jenkins, Liang Chen, Barry N. Kreiswirth
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	carbapenem carbapenemase colistin Enterobacter mcr-9 VIM Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0b8e118714594bccadecadd8003f52c8
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spelling	oai:doaj.org-article:0b8e118714594bccadecadd8003f52c82021-11-15T15:27:33ZFirst Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient10.1128/mSphere.00629-192379-5042https://doaj.org/article/0b8e118714594bccadecadd8003f52c82019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00629-19https://doaj.org/toc/2379-5042ABSTRACT An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9. IMPORTANCE We describe the complete genome assembly and sequence of a clinical Enterobacter isolate harboring both blaVIM-4 and mcr-9 recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an Enterobacter isolate harboring both blaVIM-4 and mcr-9 from the United States. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.Kalyan D. ChavdaLars F. WestbladeMichael J. SatlinAndrew C. HemmertMariana CastanheiraStephen G. JenkinsLiang ChenBarry N. KreiswirthAmerican Society for MicrobiologyarticlecarbapenemcarbapenemasecolistinEnterobactermcr-9VIMMicrobiologyQR1-502ENmSphere, Vol 4, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbapenem carbapenemase colistin Enterobacter mcr-9 VIM Microbiology QR1-502
spellingShingle	carbapenem carbapenemase colistin Enterobacter mcr-9 VIM Microbiology QR1-502 Kalyan D. Chavda Lars F. Westblade Michael J. Satlin Andrew C. Hemmert Mariana Castanheira Stephen G. Jenkins Liang Chen Barry N. Kreiswirth First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
description	ABSTRACT An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9. IMPORTANCE We describe the complete genome assembly and sequence of a clinical Enterobacter isolate harboring both blaVIM-4 and mcr-9 recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an Enterobacter isolate harboring both blaVIM-4 and mcr-9 from the United States. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The mcr-9 gene is located between two insertion elements, IS903 and IS1, but lacks the downstream regulatory genes (qseC and qseB) found in other isolates that harbor mcr-9.
format	article
author	Kalyan D. Chavda Lars F. Westblade Michael J. Satlin Andrew C. Hemmert Mariana Castanheira Stephen G. Jenkins Liang Chen Barry N. Kreiswirth
author_facet	Kalyan D. Chavda Lars F. Westblade Michael J. Satlin Andrew C. Hemmert Mariana Castanheira Stephen G. Jenkins Liang Chen Barry N. Kreiswirth
author_sort	Kalyan D. Chavda
title	First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
title_short	First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
title_full	First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
title_fullStr	First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
title_full_unstemmed	First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient
title_sort	first report of <italic toggle="yes">bla</italic><sub>vim-4</sub>- and <italic toggle="yes">mcr-9</italic>-coharboring <italic toggle="yes">enterobacter</italic> species isolated from a pediatric patient
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/0b8e118714594bccadecadd8003f52c8
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First Report of <italic toggle="yes">bla</italic><sub>VIM-4</sub>- and <italic toggle="yes">mcr-9</italic>-Coharboring <italic toggle="yes">Enterobacter</italic> Species Isolated from a Pediatric Patient

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