Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

Controlled delivery of siRNA is important for potential clinical applications. Here, the authors report on the use of cascade hybridization of DNA hairpins with ATP aptamers in DNA crosslinked polymer nanoparticles for triggered release of siRNA and demonstrate anticancer applications.

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Autores principales: Feng Li, Wenting Yu, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0b900c23e8e042f7a6171cf020923665
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spelling oai:doaj.org-article:0b900c23e8e042f7a6171cf0209236652021-12-02T14:21:30ZSpatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery10.1038/s41467-021-21442-72041-1723https://doaj.org/article/0b900c23e8e042f7a6171cf0209236652021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21442-7https://doaj.org/toc/2041-1723Controlled delivery of siRNA is important for potential clinical applications. Here, the authors report on the use of cascade hybridization of DNA hairpins with ATP aptamers in DNA crosslinked polymer nanoparticles for triggered release of siRNA and demonstrate anticancer applications.Feng LiWenting YuJiaojiao ZhangYuhang DongXiaohui DingXinhua RuanZi GuDayong YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Feng Li
Wenting Yu
Jiaojiao Zhang
Yuhang Dong
Xiaohui Ding
Xinhua Ruan
Zi Gu
Dayong Yang
Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
description Controlled delivery of siRNA is important for potential clinical applications. Here, the authors report on the use of cascade hybridization of DNA hairpins with ATP aptamers in DNA crosslinked polymer nanoparticles for triggered release of siRNA and demonstrate anticancer applications.
format article
author Feng Li
Wenting Yu
Jiaojiao Zhang
Yuhang Dong
Xiaohui Ding
Xinhua Ruan
Zi Gu
Dayong Yang
author_facet Feng Li
Wenting Yu
Jiaojiao Zhang
Yuhang Dong
Xiaohui Ding
Xinhua Ruan
Zi Gu
Dayong Yang
author_sort Feng Li
title Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
title_short Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
title_full Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
title_fullStr Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
title_full_unstemmed Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery
title_sort spatiotemporally programmable cascade hybridization of hairpin dna in polymeric nanoframework for precise sirna delivery
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0b900c23e8e042f7a6171cf020923665
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AT wentingyu spatiotemporallyprogrammablecascadehybridizationofhairpindnainpolymericnanoframeworkforprecisesirnadelivery
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AT zigu spatiotemporallyprogrammablecascadehybridizationofhairpindnainpolymericnanoframeworkforprecisesirnadelivery
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