Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

Controlled delivery of siRNA is important for potential clinical applications. Here, the authors report on the use of cascade hybridization of DNA hairpins with ATP aptamers in DNA crosslinked polymer nanoparticles for triggered release of siRNA and demonstrate anticancer applications.

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Autores principales: Feng Li, Wenting Yu, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/0b900c23e8e042f7a6171cf020923665
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