Spike-threshold adaptation predicted by membrane potential dynamics in vivo.

Neurons encode information in sequences of spikes, which are triggered when their membrane potential crosses a threshold. In vivo, the spiking threshold displays large variability suggesting that threshold dynamics have a profound influence on how the combined input of a neuron is encoded in the spi...

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Auteurs principaux:	Bertrand Fontaine, José Luis Peña, Romain Brette
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2014
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/0b944c9311c74a3a829ab5662228b199
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id	oai:doaj.org-article:0b944c9311c74a3a829ab5662228b199
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spelling	oai:doaj.org-article:0b944c9311c74a3a829ab5662228b1992021-11-18T05:52:59ZSpike-threshold adaptation predicted by membrane potential dynamics in vivo.1553-734X1553-735810.1371/journal.pcbi.1003560https://doaj.org/article/0b944c9311c74a3a829ab5662228b1992014-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24722397/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Neurons encode information in sequences of spikes, which are triggered when their membrane potential crosses a threshold. In vivo, the spiking threshold displays large variability suggesting that threshold dynamics have a profound influence on how the combined input of a neuron is encoded in the spiking. Threshold variability could be explained by adaptation to the membrane potential. However, it could also be the case that most threshold variability reflects noise and processes other than threshold adaptation. Here, we investigated threshold variation in auditory neurons responses recorded in vivo in barn owls. We found that spike threshold is quantitatively predicted by a model in which the threshold adapts, tracking the membrane potential at a short timescale. As a result, in these neurons, slow voltage fluctuations do not contribute to spiking because they are filtered by threshold adaptation. More importantly, these neurons can only respond to input spikes arriving together on a millisecond timescale. These results demonstrate that fast adaptation to the membrane potential captures spike threshold variability in vivo.Bertrand FontaineJosé Luis PeñaRomain BrettePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 4, p e1003560 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bertrand Fontaine José Luis Peña Romain Brette Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
description	Neurons encode information in sequences of spikes, which are triggered when their membrane potential crosses a threshold. In vivo, the spiking threshold displays large variability suggesting that threshold dynamics have a profound influence on how the combined input of a neuron is encoded in the spiking. Threshold variability could be explained by adaptation to the membrane potential. However, it could also be the case that most threshold variability reflects noise and processes other than threshold adaptation. Here, we investigated threshold variation in auditory neurons responses recorded in vivo in barn owls. We found that spike threshold is quantitatively predicted by a model in which the threshold adapts, tracking the membrane potential at a short timescale. As a result, in these neurons, slow voltage fluctuations do not contribute to spiking because they are filtered by threshold adaptation. More importantly, these neurons can only respond to input spikes arriving together on a millisecond timescale. These results demonstrate that fast adaptation to the membrane potential captures spike threshold variability in vivo.
format	article
author	Bertrand Fontaine José Luis Peña Romain Brette
author_facet	Bertrand Fontaine José Luis Peña Romain Brette
author_sort	Bertrand Fontaine
title	Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
title_short	Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
title_full	Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
title_fullStr	Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
title_full_unstemmed	Spike-threshold adaptation predicted by membrane potential dynamics in vivo.
title_sort	spike-threshold adaptation predicted by membrane potential dynamics in vivo.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0b944c9311c74a3a829ab5662228b199
work_keys_str_mv	AT bertrandfontaine spikethresholdadaptationpredictedbymembranepotentialdynamicsinvivo AT joseluispena spikethresholdadaptationpredictedbymembranepotentialdynamicsinvivo AT romainbrette spikethresholdadaptationpredictedbymembranepotentialdynamicsinvivo
_version_	1718424647489290240

Spike-threshold adaptation predicted by membrane potential dynamics in vivo.

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