Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK11/KEAP1 alterations) and type II (TP53 and RB1 ina...
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Nature Portfolio
2018
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oai:doaj.org-article:0b984304ba014836a34f2b6d1a57b3352021-12-02T15:34:08ZIntegrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors10.1038/s41467-018-03099-x2041-1723https://doaj.org/article/0b984304ba014836a34f2b6d1a57b3352018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03099-xhttps://doaj.org/toc/2041-1723The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK11/KEAP1 alterations) and type II (TP53 and RB1 inactivation).Julie GeorgeVonn WalterMartin PeiferLudmil B. AlexandrovDanila SeidelFrauke LeendersLukas MaasChristian MüllerIlona DahmenTiffany M. DelhommeMaude ArdinNoemie LeblayGraham ByrnesRuping SunAurélien De ReyniesAnne McLeer-FlorinGraziella BoscoFlorian MalchersRoopika MenonJanine AltmüllerChristian BeckerPeter NürnbergViktor AchterUlrich LangPeter M. SchneiderMagdalena BogusMatthew G. SolowayMatthew D. WilkersonYupeng CunJames D. McKayDenis Moro-SibilotChristian G. BrambillaSylvie LantuejoulNicolas LemaitreAlex SoltermannWalter WederVerena TischlerOdd Terje BrustugunMarius Lund-IversenÅslaug HellandSteinar SolbergSascha AnsénGavin WrightBenjamin SolomonLuca RozUgo PastorinoIver PetersenJoachim H. ClementJörg SängerJürgen WolfMartin VingronThomas ZanderSven PernerWilliam D. TravisStefan A. HaasMagali OlivierMatthieu FollReinhard BüttnerDavid Neil HayesElisabeth BrambillaLynnette Fernandez-CuestaRoman K. ThomasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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DOAJ |
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EN |
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Science Q Julie George Vonn Walter Martin Peifer Ludmil B. Alexandrov Danila Seidel Frauke Leenders Lukas Maas Christian Müller Ilona Dahmen Tiffany M. Delhomme Maude Ardin Noemie Leblay Graham Byrnes Ruping Sun Aurélien De Reynies Anne McLeer-Florin Graziella Bosco Florian Malchers Roopika Menon Janine Altmüller Christian Becker Peter Nürnberg Viktor Achter Ulrich Lang Peter M. Schneider Magdalena Bogus Matthew G. Soloway Matthew D. Wilkerson Yupeng Cun James D. McKay Denis Moro-Sibilot Christian G. Brambilla Sylvie Lantuejoul Nicolas Lemaitre Alex Soltermann Walter Weder Verena Tischler Odd Terje Brustugun Marius Lund-Iversen Åslaug Helland Steinar Solberg Sascha Ansén Gavin Wright Benjamin Solomon Luca Roz Ugo Pastorino Iver Petersen Joachim H. Clement Jörg Sänger Jürgen Wolf Martin Vingron Thomas Zander Sven Perner William D. Travis Stefan A. Haas Magali Olivier Matthieu Foll Reinhard Büttner David Neil Hayes Elisabeth Brambilla Lynnette Fernandez-Cuesta Roman K. Thomas Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| description |
The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK11/KEAP1 alterations) and type II (TP53 and RB1 inactivation). |
| format |
article |
| author |
Julie George Vonn Walter Martin Peifer Ludmil B. Alexandrov Danila Seidel Frauke Leenders Lukas Maas Christian Müller Ilona Dahmen Tiffany M. Delhomme Maude Ardin Noemie Leblay Graham Byrnes Ruping Sun Aurélien De Reynies Anne McLeer-Florin Graziella Bosco Florian Malchers Roopika Menon Janine Altmüller Christian Becker Peter Nürnberg Viktor Achter Ulrich Lang Peter M. Schneider Magdalena Bogus Matthew G. Soloway Matthew D. Wilkerson Yupeng Cun James D. McKay Denis Moro-Sibilot Christian G. Brambilla Sylvie Lantuejoul Nicolas Lemaitre Alex Soltermann Walter Weder Verena Tischler Odd Terje Brustugun Marius Lund-Iversen Åslaug Helland Steinar Solberg Sascha Ansén Gavin Wright Benjamin Solomon Luca Roz Ugo Pastorino Iver Petersen Joachim H. Clement Jörg Sänger Jürgen Wolf Martin Vingron Thomas Zander Sven Perner William D. Travis Stefan A. Haas Magali Olivier Matthieu Foll Reinhard Büttner David Neil Hayes Elisabeth Brambilla Lynnette Fernandez-Cuesta Roman K. Thomas |
| author_facet |
Julie George Vonn Walter Martin Peifer Ludmil B. Alexandrov Danila Seidel Frauke Leenders Lukas Maas Christian Müller Ilona Dahmen Tiffany M. Delhomme Maude Ardin Noemie Leblay Graham Byrnes Ruping Sun Aurélien De Reynies Anne McLeer-Florin Graziella Bosco Florian Malchers Roopika Menon Janine Altmüller Christian Becker Peter Nürnberg Viktor Achter Ulrich Lang Peter M. Schneider Magdalena Bogus Matthew G. Soloway Matthew D. Wilkerson Yupeng Cun James D. McKay Denis Moro-Sibilot Christian G. Brambilla Sylvie Lantuejoul Nicolas Lemaitre Alex Soltermann Walter Weder Verena Tischler Odd Terje Brustugun Marius Lund-Iversen Åslaug Helland Steinar Solberg Sascha Ansén Gavin Wright Benjamin Solomon Luca Roz Ugo Pastorino Iver Petersen Joachim H. Clement Jörg Sänger Jürgen Wolf Martin Vingron Thomas Zander Sven Perner William D. Travis Stefan A. Haas Magali Olivier Matthieu Foll Reinhard Büttner David Neil Hayes Elisabeth Brambilla Lynnette Fernandez-Cuesta Roman K. Thomas |
| author_sort |
Julie George |
| title |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| title_short |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| title_full |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| title_fullStr |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| title_full_unstemmed |
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| title_sort |
integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0b984304ba014836a34f2b6d1a57b335 |
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