Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish

The role of mechanical signals in early development are not fully understood. Here, the authors use the simplicity of early killifish embryos to show that tension arising from extra-embryonic epithelial expansion directs the spreading of mesenchymal-like embryonic cells during early morphogenesis.

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Bibliographic Details
Main Authors: Germán Reig, Mauricio Cerda, Néstor Sepúlveda, Daniela Flores, Victor Castañeda, Masazumi Tada, Steffen Härtel, Miguel L. Concha
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/0b9b87f39cac4dc8b802f17c1ba4259f
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Summary:The role of mechanical signals in early development are not fully understood. Here, the authors use the simplicity of early killifish embryos to show that tension arising from extra-embryonic epithelial expansion directs the spreading of mesenchymal-like embryonic cells during early morphogenesis.